Muscle Physiology and Disorders

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Latest in Muscle Physiology and Disorders

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Plasma proteomics identifies an IL-6 -associated SAA axis linked to muscle wasting and survival in patients with cancer cachexia
bioRxiv · 21 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.06.11.730788
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Duchenne muscular dystrophy is associated with defective membrane repair and dysregulation of annexin-A1/A2 in skeletal muscle
bioRxiv · 14 Oct 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.09.23.677988
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MetAR: A semi-automated meta-analysis of skeletal muscle androgen receptors association with age
bioRxiv · 14 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.04.21.719741
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A health-system-scale, episode-resolved multimodal atlas of cancer cachexia.
Nature Medicine · 12 Oct 2026 · Journal Article
Longitudinal clinicogenomic data from over 52,000 cancer patients reveal cachectic weight loss episodes cluster near disease progression and are linked to worse outcomes across cancer types.
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https://jclub.com.au/a/42864412
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Endothelial Piezo1 regulates muscle AKT abundance and mechanically induced muscle hypertrophy
bioRxiv · 8 Oct 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.09.02.673617
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Integrative Multi-omics Analysis of the Human Skeletal Muscle Response to Endurance or Resistance Exercise: Findings from the Molecular Transducers of Physical Activity Consortium (MoTrPAC)
bioRxiv · 8 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.03.04.705181
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Hippo-YAP1/TAZ-TEAD signaling coordinates myoblast fusion and sarcomere assembly in skeletal muscle development
bioRxiv · 8 Oct 2026 · Preprint
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https://jclub.com.au/a/10.1101/2024.06.11.598443
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An ALLO-1-associated network links mitochondrial quality control to functional recovery in structurally compromised muscle.
Communications Biology · 6 Oct 2026 · Journal Article
ALLO-1 regulates mitochondrial stress responses and enables muscle functional recovery before structural repair in C. elegans muscle.
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https://jclub.com.au/a/42875476
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A novel ex vivo model of nerve-induced skeletal muscle contraction
bioRxiv · 6 Oct 2026 · Preprint
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https://jclub.com.au/a/10.1101/2024.10.10.613648
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Identifying fundamental properties of neuromuscular disorder genes through genomic feature analysis
bioRxiv · 6 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.04.21.719902
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Aging remodels the human muscle secretome, impairing stem cell via sphingolipid metabolism
bioRxiv · 2 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.10.01.755640
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Familial Parkinson's Disease Mutations Converge on Alternative Splicing Programs Linked to Lysosomal, Autophagic and Vesicle Trafficking Pathways
bioRxiv · 1 Oct 2026 · Preprint
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https://jclub.com.au/a/10.1101/2024.02.28.582420
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Exploring the potential targets and possible mechanisms of Shenqi Fuzheng Injection in the treatment of cancer-associated muscle wasting based on network pharmacology.
Frontiers in Genetics · 1 Oct 2026 · Journal Article
Shenqi Fuzheng Injection may target Caspase-3 and Caspase-8 to reduce apoptosis in cancer-associated muscle wasting, with key components showing strong binding affinity.
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https://jclub.com.au/a/42889212
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FBXL21 regulates diurnal proteostasis in skeletal muscle by targeting DNAJB6 and client proteins.
EMBO Reports · 30 Sept 2026 · Journal Article
FBXL21 regulates diurnal proteostasis in skeletal muscle by mediating degradation of DNAJB6 and its client proteins, including Desmin and TDP-43.
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https://jclub.com.au/a/42816597
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Muscle Fiber- and Cell Type-Specificity of Training Adaptation in Male Mice
bioRxiv · 30 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.11.04.686534
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KLHL40 gene replacement therapy in severe nemaline myopathy improves survival and skeletal muscle function in a preclinical mouse model
bioRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.23.753846
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Echo intensity is not an accurate surrogate marker of intramuscular fat and fibrosis: A systematic review with meta-analyses
medRxiv · 24 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.19.26363379
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Pathophysiological remodeling of the skeletal muscle microenvironment in patients with lung cancer
bioRxiv · 22 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.11.19.689342
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Arginine Kinase 1 supports energy homeostasis in Drosophila flight muscle development.
PLOS Genetics · 17 Sept 2026 · Journal Article
Arginine kinase 1 is essential for flight muscle development and function in Drosophila, with its depletion causing severe muscle defects and animal lethality.
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Gene co-expression networks reveal differential developmental modularity in Mammalian limbs
bioRxiv · 15 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.05.07.723669
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Loss of LanC-like proteins impairs post-injury regeneration of aging muscles
bioRxiv · 14 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.05.15.725287
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Reduced Myonuclear Number Is Accompanied by More Regular Longitudinal Nuclear Positioning During Muscle Growth
bioRxiv · 11 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.05.05.722961
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Functional primary human 3D skeletal muscle models enable exercise and metabolic research
bioRxiv · 9 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.06.29.735246
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Potential of GDF15 goes beyond its role as a non-invasive biomarker for MASLD.
Gut · 7 Sept 2026 · Letter
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https://jclub.com.au/a/41326207
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Strengthening muscle for healthy ageing: innovative treatments for sarcopenia.
Nature Reviews Drug Discovery · 7 Sept 2026 · Review
Pharmacological strategies targeting multiple cellular pathways show promise in combating sarcopenia, a major cause of frailty in aging populations, with recent clinical trials indicating progress.
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https://jclub.com.au/a/42706321
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Spectrum and carrier frequency of DMD in Yueyang, China: a population-based analysis using NGS and MLPA.
Frontiers in Genetics · 3 Sept 2026 · Journal Article
Duchenne muscular dystrophy carrier frequency is 0.11% in Yueyang, China, with a high prevalence of exon 45-55 deletions and significant regional variation.
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https://jclub.com.au/a/42751392
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Myogenic differentiation-derived small extracellular vesicles as a therapeutic strategy for miR-193b-3p-mediated muscle regeneration.
Molecular therapy. Nucleic acids · 3 Sept 2026 · Journal Article
Small extracellular vesicle-delivered miR-193b-3p enhances muscle regeneration by suppressing AP2M1 in vitro and in a murine muscle loss model.
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https://jclub.com.au/a/42823972
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Self-organization of vascularized muscle from bovine embryonic stem cells.
Nature Communications · 2 Sept 2026 · Journal Article
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https://jclub.com.au/a/42686746
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Sex- and fiber type-specific remodeling of the muscle proteome implicates CSRP3 in resistance training-induced hypertrophy.
Nature Communications · 2 Sept 2026 · Journal Article
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https://jclub.com.au/a/42823422
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Generation and characterization of human induced pluripotent stem cell line AUSCIi001-A from spinal muscular atrophy patient.
Stem cell research · 1 Sept 2026 · Journal Article
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https://jclub.com.au/a/42632224
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