Cumulative transcription factor binding and p300 activity determine enhancer activation frequency in eukaryotic cells.
- 1 cited this week
Genomics and Chromatin Dynamics
Moving in Nature Genetics.
- Moved, week to 23 Oct 2026
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scE2G models predict enhancer-gene interactions with over 80% accuracy across diverse human cell types, advancing understanding of gene regulation and disease genetics.
- 29 cites
Latest in Genomics and Chromatin Dynamics
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Variant effects in MPRAs are highly dependent on their position within the construct, with expression change magnitudes varying substantially based on placement.
- Open access
Stabilizing G-quadruplexes with pyridostatin reduces NF-κB-dependent inflammatory gene expression in lipopolysaccharide-stimulated mouse macrophages.
- Open access
DNACipher predicts the effects of genetic variants across 38,582 cell type/assay combinations, over six times more contexts than previous models, enabling comprehensive variant impact analysis.
- Open access
- 2 cites
Monocyte-lineage expansion is linked to transcriptomic individuality in genetically identical Dasypus novemcinctus quadruplets, with the most distinct individual showing increased monocytes.
- Open access
EZHIP evolved rapidly under positive selection in primates and exhibits dynamic expansions and losses across mammalian species, especially in placental mammals.
- Open access
- 2 cites
Electrostatic attraction alone can compact and sequester fragmented chromatin during apoptosis, preventing DNA release into extracellular vesicles.
- Open access
Multiple chromosome-specific mechanisms suppress axis protein deposition and DNA double-strand breaks within 20 kb of telomeres in Saccharomyces cerevisiae.
- Open access
Ubiquitin-dependent fate control and isoform diversity safeguard ZUP1, a key ubiquitin chain-editing enzyme, maintaining RPA turnover on ssDNA in cells.
- Open access
The NuRD complex modulates RNA polymerase III activity at highly expressed tRNA gene clusters, influencing the cellular tRNA pool's dynamic range.
- Open access
Bicon-seq identifies Gas5 as a highly conserved, essential lncRNA associated with NUP98::KDM5A onco-condensates in AML cells.
- Open access
Reduced distance between pre-mRNA 3' cleavage and transcription termination correlates with increased gene expression in colorectal cancer cells.
- Open access
The PyKNOX-PyHDAC2 complex suppresses PyCAND1 expression during sporophytic development in Pyropia yezoensis, with a strong negative correlation observed in diploid stages.
- Open access
Genetic deletion of Zbtb44 causes spontaneous colitis and rectal prolapse in mice, with Zbtb44 -/- T cells showing increased IFN-γ expression.
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Topics moving, week to 23 Oct 2026
- Single-cell and spatial transcriptomics6
- Neuroinflammation and Neurodegeneration Mechanisms5
- Bacteriophages and microbial interactions5
- Gut microbiota and health5
- Genomics and Phylogenetic Studies4
- Cancer Genomics and Diagnostics4
- Cancer Immunotherapy and Biomarkers4
- Alzheimer's disease research and treatments3
- Inflammatory Bowel Disease3
- Influenza Virus Research Studies3