Advanced biosensing and bioanalysis techniques

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Moved, week to 23 Oct 2026: 1
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Chemical engineering of nucleic acid nanodevices: From molecular modification to biomedical applications.
Molecular therapy. Nucleic acids · 8 Oct 2026 · News
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G4All: a database of experimentally confirmed G-quadruplex-forming sequences.
Nucleic Acids Research · 21 Oct 2026 · Journal Article
G4All provides the first comprehensive, curated database of experimentally validated G-quadruplex-forming DNA and RNA sequences with negative controls.
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https://jclub.com.au/a/42904357
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Correction: Stall force measurement of the kinesin-3 motor KIF1A using a programmable DNA origami nanospring.
eLife · 21 Oct 2026 · Published Erratum
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Decoding coupled epigenetic-fragmentomic signals in circulating cell-free DNA for interpretable cancer diagnosis.
Genome Medicine · 15 Oct 2026 · Journal Article
Partial preservation of cfDNA fragmentomic signals in methylation sequencing enables effective cancer detection models with the strongest performance from genome-wide integration.
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https://jclub.com.au/a/42888434
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A modular lentiviral system for multiplexed gene perturbation and functional analysis suggests interdependence of hormone receptors in breast cancer growth in vivo
bioRxiv · 14 Oct 2026 · Preprint
A modular lentiviral system enables multiplexed gene perturbation revealing hormone receptor interdependence in breast cancer growth in vivo.
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https://jclub.com.au/a/10.64898/2025.12.07.692832
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Panel-level multilocus methylation quantification in native cell-free DNA by PCR-compatible sequential enzymatic processing
medRxiv · 9 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.06.11.26354897
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Cell-free systems enable mechanistic characterization of genetically encoded RNA strand exchange circuits for programmable protein expression, logic, and biosensing
bioRxiv · 8 Oct 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.09.25.678518
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AntiCapt: Fine-Tuned Nucleotide Language Models for Predicting and Designing Anticancer Aptamers
bioRxiv · 7 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.28.754914
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RNA structure modulates Cas13 activity and enables mismatch detection.
Nature Biotechnology · 1 Oct 2026 · Journal Article
Secondary structure in target RNAs inhibits Cas13 activity, but strand displacement can enhance mismatch discrimination up to 50-fold in cellular environments.
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https://jclub.com.au/a/41131153
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3D DNA walker-based biosensors: From programmable trajectory to detection of foodborne pathogens.
Biotechnology advances · 1 Oct 2026 · Review
3D DNA walker-based biosensors can detect foodborne pathogens with high sensitivity through programmable motion control and signal amplification.
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https://jclub.com.au/a/42263833
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Tunable, proteolytic dosage control of CRISPR-Cas systems enables precise gene therapy for dosage sensitive disorders
bioRxiv · 30 Sept 2026 · Preprint
Proteolytic control of CRISPR-Cas systems achieves precise, tunable gene expression with reduced variability, enabling improved gene therapy for dosage-sensitive disorders.
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https://jclub.com.au/a/10.1101/2024.10.09.617463
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ProPER: Ligation-free in situ proximity extension enables multiplexed molecular-state analysis
bioRxiv · 30 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.04.24.718482
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Mutanome-guided immunopeptidomics of blood plasma for neoepitope detection in solid tumors is constrained by cfDNA variant calling sensitivity and MS detection limits
bioRxiv · 26 Sept 2026 · Preprint
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Scaling of structural variability of ecDNA polymer condensates with copy number boosts and stabilises oncogene regulatory contacts
bioRxiv · 26 Sept 2026 · Preprint
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A portable N-terminal biphenyl motif in LL-37 enhances the activity of short human cathelicidin derivatives
bioRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.05.22.655619
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AptViralDB: A repository of experimentally validated antiviral aptamers.
Molecular therapy. Nucleic acids · 23 Sept 2026 · Review
AptViralDB provides a comprehensive, manually curated database of 1,768 experimentally validated antiviral aptamers targeting 40 viral species and 104 molecular targets.
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https://jclub.com.au/a/42889724
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In utero and neonatal lipid nanoparticle delivery achieves robust editing in hematopoietic stem cells.
bioRxiv · 22 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.05.12.652147
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VIPR RNA-guided DNA recognition by noncontiguous geometric triplex formation.
Science · 17 Sept 2026 · Journal Article
VIPR systems achieve precise DNA targeting through noncontiguous triplex formation, with 21 cryo-EM structures revealing the mechanism of target engagement.
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https://jclub.com.au/a/42752121
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Transcriptome-wide mapping reveals a non-canonical RNA-dependent mechanism of platinum cancer drugs
bioRxiv · 16 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2025.12.20.694502
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Lipid tail chemistry regulates selective membrane interactions with model DNA nanoprobes and DNA-based coacervates
bioRxiv · 15 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.10.11.681803
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pH-responsive synthetic cells for controlled protein synthesis and release
bioRxiv · 5 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.11.16.688650
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Hybridization chain reaction variants with enhanced sensitivity for detecting challenging mRNA targets
bioRxiv · 3 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.09.09.675218
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A thermodynamically favoured molecular computer.
Nature · 1 Sept 2026 · Journal Article
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https://jclub.com.au/a/42749917
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Protein nanocages empower RNA profiling.
Nature Methods · 1 Sept 2026 · Journal Article
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Precise DNA base editing using ContactSeek.
Nature Methods · 1 Sept 2026 · Journal Article
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Towards density-optimal DNA storage with practical bijective coding.
Nature Communications · 27 Aug 2026 · Journal Article
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