PanGBank provides precomputed pangenomes for over 4600 prokaryotic species, covering more than 393,000 genomes, enabling large-scale comparative genomics.
- 1 cited this week
Nucleic Acids Research
Oxford University Press · Genomics & Bioinformatics · ISSN 0305-1048, 1362-4962
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- 17.4
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- 869
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- 99%
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- Papers this month
- 37
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NTDB catalogs 118 naturally transformable prokaryotic species, 1072 transformation-associated genes, and 10 DNA uptake motifs, providing a comprehensive resource for natural transformation research.
G4All provides the first comprehensive, curated database of experimentally validated G-quadruplex-forming DNA and RNA sequences with negative controls.
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G4All provides the first comprehensive, curated database of experimentally validated G-quadruplex-forming DNA and RNA sequences with negative controls.
- Open access
HRD consolidates 814 multi-omics records and clinical data into a unified resource for human reproduction and development research.
EvoNiche reveals 5609 spatial niches and reconstructs tissue- and cell-level spatiotemporal trajectories across 35 cancer types.
NTDB catalogs 118 naturally transformable prokaryotic species, 1072 transformation-associated genes, and 10 DNA uptake motifs, providing a comprehensive resource for natural transformation research.
RNAffinityDB compiles 10,016 curated experimental RNA-protein binding affinity records from over 1,000 publications, linking 3,057 protein constructs and 4,638 RNA sequences.
ImmunEscpMap catalogs 55,711 gene-evidence records linking immune escape mechanisms in cancer and viral infection, involving 667 genes across diverse evidence types.
PAZy now contains over 450 experimentally validated plastics-active enzymes, with expanded metadata, substrate coverage, and improved curation, enhancing enzyme discovery efforts.
CLEAN Database predicts enzyme functions for over 55 million sequences across 1,098,305 strains, advancing enzyme annotation coverage significantly.
DRAMP 5.0 introduces a novel FASTS format that integrates sequence and structural information, with 22,298 entries annotated in this format, enhancing AMP data resources.
OAS-nano is the first large-scale, web-accessible database containing over 73 million unique VHH sequences from camelid species.
AlphaFold 3 achieves over 80% success in modeling 1039 nucleic acid and nucleic acid-protein structures with modified nucleotides, but accuracy varies for modifications not in training data.
Long, chemically stabilized antisense oligonucleotides longer than 24 nucleotides can impair RNA exosome function by binding to its catalytic subunits.
MAD3-MAD4 forms a 2:2 heterotetramer that activates ATPase and DNA cleavage functions in the Pseudomonas aeruginosa MADS defense system.
RpoS in Escherichia coli orchestrates a metabolic reprogramming by activating 667 genes, with metabolic genes surpassing stress-response targets in the regulon.
Srs2 helicase and Rrp1 translocase differentially regulate Rad51-DNA interactions in fission yeast, targeting distinct Rad51 pools through substrate specificity.
PML-1 contains a unique nucleic acid-binding domain, PXL, that specifically binds G-rich oligonucleotides and polyUG RNA, influencing nuclear functions.
ZBP1's Zα domains specifically bind pre-formed Z-RNA and cannot flip unmodified dsRNA into the Z-conformation, unlike ADAR1's Zα domain.
TdT uses deoxyribonucleoside diphosphates with reduced rates and efficiencies but similar activation energies to dNTPs, indicating γ-phosphate's role in nucleotide discrimination.
IGUA is a scalable and flexible gene cluster family delineation method that is 29 times faster than the current state-of-the-art, without losing accuracy.
RiboBA enhances ncORF identification in Ribo-seq data by accurately modeling protocol-induced biases, especially in datasets with attenuated periodicity.
TET enzymes' oxidation of 5-methylcytosine is influenced by sequence context, affecting 5hmC persistence and shaping DNA hydroxymethylation landscapes.
UbiBrowser 3.0 characterizes 776 human E3 ubiquitin ligase-substrate interactions with detailed ubiquitin chain type associations and cellular effects.
MBD2 protein exhibits a bistable equilibrium between high-affinity and reduced-affinity conformations when recognizing methylated CpG DNA, with S189 as a key macro-switch.
A platinum-associated double-base substitution signature with GG deletion as the dominant feature was identified in a large pan-cancer metastatic cohort.
HURDLER enables cloning of designed armadillo repeat proteins with up to 85 internal modules, exceeding previous length limits and facilitating structural studies.
ANeR uncovers a conserved translational fingerprint shared by mitotic and meiotic M-phases, identifying proteins with increased accumulation during both divisions.
Remdesivir inhibits viral RdRP translocation at least 100-fold more effectively than adenosine, significantly impacting the nucleotide addition cycle in enterovirus RdRP.
CircACVR2A(2-4) regulates stem cell pluripotency by uncoupling CAK complex activity, affecting neuroectoderm differentiation and RNAPII phosphorylation.
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- bioRxiv6131
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- PNAS447
- Sci Adv354
- JAMA262
- Environ Res230
- BMJ182
- Environ Pollution165
- Nat Commun161
- Science141
- Nature138
- Lancet128
- Cell Rep120
- NEJM119
- mBio107
- Plant Cell Environ107
- Curr Biol106
- J Exp Bot106
Topics moving, week to 23 Oct 2026
- Single-cell and spatial transcriptomics6
- Neuroinflammation and Neurodegeneration Mechanisms5
- Bacteriophages and microbial interactions5
- Gut microbiota and health5
- Genomics and Phylogenetic Studies4
- Cancer Genomics and Diagnostics4
- Cancer Immunotherapy and Biomarkers4
- Alzheimer's disease research and treatments3
- Inflammatory Bowel Disease3
- Influenza Virus Research Studies3