Non-genetic variation in red blood cell hemoglobin content modulates nutrient consumption by Plasmodium falciparum, with infected cells amplifying this variability to over 100%.
- Open access
Malaria Research and Control
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WNV infection induces durable neutralizing antibodies with a half-life of up to 472 days, but cross-reactivity against divergent lineages varies significantly among individuals.
- Open access
Heterozygous HbS is strongly associated with parasites carrying Pfsa+ alleles in asymptomatic P. falciparum infections, indicating a selective advantage for these alleles in HbS carriers.
Mutations in Plasmodium falciparum's CLAG3 paralogs are linked to a 50% reduction in sickle hemoglobin's protective effect against malaria.
- Open access
Plasmodium sporozoite cell traversal triggers innate immune responses that are essential for protective T cell activation, with traversal-deficient SPZs failing to prime immunity in mice.
- 1 cites
Active migration of Plasmodium sporozoites through host cells is essential for sterilizing T cell-mediated immunity in rodent vaccination models.
- Open access
- 1 cites
AP2-HS is essential for environmental induction of gdv1 expression and sexual conversion in Plasmodium falciparum, involving a positive-negative feedback loop.
Acyl carrier protein is vital for apicoplast biogenesis in Plasmodium falciparum blood-stage parasites, independent of its role in fatty acid synthesis, with knockout being lethal.
- Open access
Multiple local PfDHFR I164L haplotypes have expanded in Uganda, increasing pyrimethamine resistance from 19.4% to 32.4% between 2016 and 2022.
- Open access
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Topics moving, week to 23 Oct 2026
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- Alzheimer's disease research and treatments3
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