MSA Pairformer predicts protein-protein interface contacts nearly 3 times more accurately than existing methods, despite training only on individual chains.
- Open access
- 2 cites
Machine Learning in Bioinformatics
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ProVADA enables functional protein redesign, converting human renin into an active cytosolic protease and deimmunizing murine antibodies with significant HLA-I binder reduction.
- Open access
RigidSSL pretraining enhances protein designability by up to 43% and improves conformational ensemble modeling in G protein-coupled receptors.
- Open access
Optimized power exponents for distance-based variables improve protein-ligand binding affinity prediction, with neural network models reaching R values between 0.800 and 0.900.
- Open access
Homology-aware cross-validation strategies reveal that current RNA secondary structure prediction methods' apparent superiority is an artifact of splitting strategies.
- Open access
PlantGeneAnn achieves a new state-of-the-art F1 score of 0.856 at the exon level in plant gene annotation across 20 species, outperforming existing tools.
- Open access
MassNet is a billion-scale AI-ready mass spectral corpus containing 1.5 billion spectra across 35 species, enabling scalable deep learning in proteomics.
- Open access
Tangermeme enables extraction of human-interpretable cis-regulatory patterns from deep learning models with high efficiency.
- Open access
SNACKKSS predicts pharmacologic gene regulators with high accuracy, identifying protein-inhibiting compounds by integrating RNA-Seq and literature data.
- Open access
Kidzoi, a kidney cell-type-specific S2F model, improves regulatory variant effect prediction by 10-23% over existing models.
- Open access
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Journals this month
- bioRxiv6131
- medRxiv1703
- PNAS447
- Sci Adv354
- JAMA262
- Environ Res230
- BMJ182
- Environ Pollution165
- Nat Commun161
- Science141
- Nature138
- Lancet128
- Cell Rep120
- NEJM119
- mBio107
- Plant Cell Environ107
- Curr Biol106
- J Exp Bot106
Topics moving, week to 23 Oct 2026
- Single-cell and spatial transcriptomics6
- Neuroinflammation and Neurodegeneration Mechanisms5
- Bacteriophages and microbial interactions5
- Gut microbiota and health5
- Genomics and Phylogenetic Studies4
- Cancer Genomics and Diagnostics4
- Cancer Immunotherapy and Biomarkers4
- Alzheimer's disease research and treatments3
- Inflammatory Bowel Disease3
- Influenza Virus Research Studies3