The AMIGa complex is at the crossroads of cytochrome c oxidase and ATP synthase biogenesis.

Loss of Aim11 in mitochondria causes accumulation of assembly intermediates of cytochrome c oxidase and ATP synthase in yeast.

• Why it matters: Understanding the assembly of oxidative phosphorylation complexes is crucial because defects can impair cellular energy production, but the specific roles of assembly factors like Aim11 remain unclear.
• What they did: The study used mitochondrial complexome profiling and protein interaction analysis to characterize Aim11, revealing its formation of the AMIGa complex with Mtc3, Iai11, and Gep7, and its interaction with the Atco complex.
• The result: Aim11 deficiency reduces respiratory growth and CIV activity, and its interaction with the Atco complex suggests a role in coordinating the biogenesis of key mitochondrial energy complexes, with human TMEM242 as a potential orthologue.