Folding a broken genome: the versatile roles of cohesin in genome maintenance.

Cohesin's dual functions in chromosome cohesion and chromatin loop extrusion are crucial for genome stability and DNA repair.

• Why it matters: Understanding cohesin's roles is vital because DNA double-strand breaks are highly toxic lesions, and effective repair is essential for preventing genomic instability and disease.
• What they did: The review discusses how cohesin maintains genome integrity through sister chromatid cohesion during mitosis and dynamic chromatin loop extrusion during interphase, especially in response to DNA double-strand breaks.
• The result: Cohesin's activities facilitate repair signaling and chromatin movements, positioning it as a key regulator of genome maintenance and chromatin architecture.