Fructose activates a distinct gut-brain pathway involving PYY and Y2 receptor neurons, leading to a markedly reduced suppression of hypothalamic AgRP neuron activity in mice.
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Diet, Metabolism, and Disease
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Metabolic dysfunction–associated steatotic liver disease affects children and adolescents, with diagnosis, treatment, and prognosis discussed in this review.
Hepatic and serum metabolite levels show weak correlation, with liver metabolites more strongly associated with steatosis and inflammation than serum metabolites in severe obesity.
A very-low-carbohydrate diet yields 2-3 times greater improvements in hepatic insulin sensitivity than Mediterranean or very-low-fat diets during 10% weight loss in metabolically unhealthy obesity.
ALG-055009 significantly reduces liver fat in non-cirrhotic adults with MASH, with up to 33.2% relative decrease at higher doses in a phase 2a trial.
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Topics moving, week to 23 Oct 2026
- Single-cell and spatial transcriptomics6
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- Alzheimer's disease research and treatments3
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