Protein Tyrosine Phosphatases
Moving in bioRxiv, Blood, Cell Reports, Circulation, Frontiers in Genetics and Plant Physiology and Biochemistry.
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Latest in Protein Tyrosine Phosphatases
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Inhibiting IL-8-CXCR1 signaling reverses hypertrophic cardiomyopathy and fibrosis in Noonan syndrome models.
- Open access
PADI1 and PADI3 promote resistance to KRAS inhibitors by sustaining mitochondrial adaptation in KRAS-driven tumors.
- Open access
In PTPN11-mutant juvenile myelomonocytic leukemia, dual NLRP3 and PTGS2 inhibition combined with MEK blockade significantly prolongs survival and reduces leukemic burden in models.
- Open access
Loss of FAP-1 causes defective megakaryocyte membrane development, impaired platelet function, and myelofibrosis-like features in mice, with 50% developing severe symptoms.
A de novo 15q11.1-q13.3 duplication with tetrasomy and trisomy was linked to severe neurodevelopmental delays and autism in a girl, expanding known genomic variations.
- Open access
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