Redox biology and oxidative stress

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Integration of hydrogen peroxide sensing and detoxification by the C. elegans nervous system.
Current Biology · 21 Oct 2026 · Journal Article
C. elegans nervous system detects and responds to environmental H2O2 through 24 neuron classes that encode stimulus intensity and exposure history.
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Multiscale modeling reveals non-linear dynamics of AKT-mediated NO-ROS crosstalk in shear stress-induced endothelial phenotype.
PLOS Computational Biology · 21 Oct 2026 · Journal Article
Multiscale modeling shows that endothelial repair under shear stress depends on nonlinear AKT/NO/ROS interactions, with a critical intervention window on Day 1.
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p66Shc mediates SUMO2-induced endothelial dysfunction.
eLife · 21 Oct 2026 · Journal Article
SUMO2 modification of p66Shc at lysine-81 mediates hyperlipidemia-induced endothelial dysfunction in mice.
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PRADA enables in vivo peroxidase proximity labeling for multiomics.
Nature Chemical Biology · 14 Oct 2026 · Journal Article
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https://jclub.com.au/a/42875543
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Regulation of PDH via cysteine oxidation on DLAT.
Nature Communications · 14 Oct 2026 · Journal Article
Cysteine oxidation of DLAT inhibits PDH activity and promotes a Warburg-like metabolic shift under oxidative stress in mouse and human tissues.
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Unstructured regions differentially modulate the activation of RBOHD and RBOHH
bioRxiv · 12 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.03.31.715192
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Evolutionarily conserved temperature dependency leads to loss of protein O-GlcNAc in mammalian hypothermia
bioRxiv · 8 Oct 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.07.08.660373
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Disease-associated protein states accessible to 8-oxoguanine transcriptional miscoding without genomic mutation
bioRxiv · 4 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.10.01.756037
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Monothiol glutaredoxin DaGrxB couples iron homeostasis with redox balance to orchestrate development and virulence in the peach shoot blight fungus Diaporthe amygdali
bioRxiv · 2 Oct 2026 · Preprint
DaGrxB, a monothiol glutaredoxin in Diaporthe amygdali, is essential for growth, reproduction, and virulence, coordinating iron homeostasis and redox balance.
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Novel perspectives on cysteine-dependent enzymes and processes in photosynthetic organisms.
Journal of Experimental Botany · 29 Sept 2026 · Review
Cysteine desulfhydrases in photosynthetic organisms produce hydrogen sulfide, which plays diverse roles in plant physiology and stress responses.
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Emerging roles of glutaredoxins in plant metabolism.
Journal of Experimental Botany · 29 Sept 2026 · Review
Glutaredoxins in plants have diversified into over 30 isoforms across four classes, with class III GRXs evolving plant-specific features that enable functional diversification.
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Identification and analysis of glutaredoxin genes in Amaranthus palmeri reveal roles in abiotic stress responses.
Plant Physiology and Biochemistry · 21 Sept 2026 · Journal Article
Identification of 12 ApGRX genes in Amaranthus palmeri shows their crucial roles in mediating responses to multiple abiotic stresses, including salt, drought, and oxidative stress.
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Hos2-mediated KatG1 decrotonylation orchestrates ROS scavenging in rice blast infection.
Nature Communications · 14 Sept 2026 · Journal Article
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Determining the dark proteome.
Nature Chemical Biology · 8 Sept 2026 · Journal Article
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OXR1 is a dual redox-mitochondrial checkpoint governing osteoclast differentiation and bone loss in an osteoporosis mouse model.
Nature Communications · 5 Sept 2026 · Journal Article
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Gene regulatory network analysis identifies auranofin as an anti-atherosclerotic drug.
Nature Communications · 2 Sept 2026 · Journal Article
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