Unidirectional cross-feeding constrains adaptive evolution in both microbial species over 800 generations, with lower mutation fixation and increased dependence observed.
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Unidirectional cross-feeding constrains adaptive evolution in both microbial species over 800 generations, with lower mutation fixation and increased dependence observed.
Competitive interactions in six-species synthetic denitrifying communities significantly enhance denitrification rates during experimental evolution.
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Unidirectional cross-feeding constrains adaptive evolution in both microbial species over 800 generations, with lower mutation fixation and increased dependence observed.
Competitive interactions in six-species synthetic denitrifying communities significantly enhance denitrification rates during experimental evolution.
Transient mitochondrial heteroplasmy in Zymoseptoria tritici enables rapid switching between fungicide resistance genotypes, with alleles G143A and Y132C coexisting within individual cells.
GISMO and GISMO-mis, two mammalian constraint metrics, strongly correlate with human gene essentiality and identify critical genes missed by existing methods, especially short genes.
Prey infection effects drive predator specialization and coexistence, with facilitation effects increasing niche overlap and virulence effects promoting predator-parasite separation.
ProVADA enables functional protein redesign, converting human renin into an active cytosolic protease and deimmunizing murine antibodies with significant HLA-I binder reduction.
Limited microgravity-specific gene requirements were found in Vibrio fischeri, with only a few genes showing differential effects under modeled microgravity versus gravity.
Small HK97-fold viral genomes linked to procapsids suggest bidirectional evolution between viruses and encapsulins.
Punctuated mutagenesis significantly enhances tumor cells' ability to cross fitness valleys, promoting multi-step adaptation in human cancers.
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