Zebrafish Biomedical Research Applications

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Laminin and Fibronectin contribute to Guided Endothelial Self-Organization during Intersegmental Vessel Formation
bioRxiv · 16 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.03.13.711615
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Chronic exposure to environmentally relevant diazepam alters behaviour, gut microbiome, and offspring phenotype in zebrafish (Danio rerio).
Environmental pollution · 15 Oct 2026 · Journal Article
Chronic exposure to environmentally relevant diazepam causes intergenerational neurobehavioral and developmental abnormalities in zebrafish, with effects observed at 1 and 10 μg/L concentrations.
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https://jclub.com.au/a/42520872
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Antagonistic developmental cardiotoxicity of fluroxypyr-meptyl and carfentrazone-ethyl in zebrafish embryos via oxidative stress and apoptosis.
Environmental pollution · 15 Oct 2026 · Journal Article
Combined exposure to fluroxypyr-meptyl and carfentrazone-ethyl exhibits antagonistic developmental cardiotoxicity in zebrafish embryos, with an LC50 of 0.766 mg/L for their mixture.
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Whole-brain neural substrates of behavioral variability in the larval zebrafish
bioRxiv · 13 Oct 2026 · Preprint
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https://jclub.com.au/a/10.1101/2024.03.03.583208
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During an inflammatory response, zebrafish tnfa and tnfb are expressed by different cell types and have distinct expression kinetics
bioRxiv · 8 Oct 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.11.04.686030
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Trial-History and Spatial Biases Shape Perceptual Decision-Making in Archerfish
bioRxiv · 8 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.06.24.734265
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Conserved cellular architecture and developmental mechanisms of the zebrafish meninges
bioRxiv · 6 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.02.14.703877
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A Gata4-Loxl2 axis controls ECM remodeling to enable scar-free spinal cord regeneration in zebrafish.
Cell Reports · 5 Oct 2026 · Journal Article
Gata4-Loxl2b axis is essential for ECM remodeling and scar-free spinal cord regeneration in zebrafish, with loss of Gata4 impairing recovery.
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https://jclub.com.au/a/42837255
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CLOK: a chemigenetic multicolor labeling system to visualize neuronal birthdate and circuit integration.
Nature Neuroscience · 30 Sept 2026 · Journal Article
CLOK enables precise multicolor labeling of neurons by birthdate, revealing distinct maturation trajectories in zebrafish visual and motor systems.
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https://jclub.com.au/a/42816554
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Social Dominance Reorganizes the Transcriptomic Neuropeptidome in a Highly Social Cichlid Fish
bioRxiv · 30 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2024.11.07.622449
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A molecular switch: Ro5-3335 drives hematopoietic stem cell division and clonality through distinct RUNX1 binding partners
bioRxiv · 29 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2024.06.07.596542
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Perceptual constraints of motion shape animal movement strategies
bioRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.22.753148
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Lateralized dopaminergic neuron activity encodes goal-directed turning
bioRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.23.753763
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Neuronal detection of social actions directs collective escape behaviour.
Nature · 23 Sept 2026 · Journal Article
Neuronal activity in the midbrain and thalamus of Danionella cerebrum encodes social escape cues, enabling collective escape behavior based on visual perception of conspecifics.
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Endothelial PERK restricts lymphoid regeneration by reducing DLL4-NOTCH3 signaling at the Pre-B niche.
Cell Reports · 22 Sept 2026 · Journal Article
Ablating endothelial PERK enhances DLL4-NOTCH3 signaling, boosting lymphoid regeneration by 50% after irradiation in hematopoietic recovery.
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Neural plate morphogenesis and pre-patterning enable specification of intermediate progenitors in the spinal cord
bioRxiv · 22 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.01.09.632276
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Hippocampal representations differentiate reactive and anticipatory responses during foraging under threat
bioRxiv · 21 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.04.17.719234
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Convergent and divergent phenotypic impacts of estradiol on neurodevelopmental disorder risk genes
bioRxiv · 19 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.02.18.706588
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An applicable and efficient retrograde monosynaptic circuit mapping tool for larval zebrafish.
eLife · 18 Sept 2026 · Journal Article
An efficient retrograde monosynaptic circuit mapping method in larval zebrafish reveals up to 20 inputs per neuron with low cytotoxicity.
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https://jclub.com.au/a/42758538
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Sex differences in exploration-exploitation strategies during home-cage decision making
bioRxiv · 17 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.04.02.716124
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Liu Y, Chen Q, Jeong H-W, et al. Dopamine signaling regulates hematopoietic stem and progenitor cell function. Blood. 2021;138(21):2051-2065.
Blood · 17 Sept 2026 · Journal Article
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https://jclub.com.au/a/42752830
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Rhomboid protease Rhbdl2 regulates macrophage recruitment and wound regeneration in zebrafish
bioRxiv · 17 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.02.13.705804
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Whole-body 3D kinematics of freely behaving Drosophila
bioRxiv · 16 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.05.03.722293
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Osmo-hydraulic volume regulation ensures robust endothelial-to-haematopoietic transition
bioRxiv · 16 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.04.09.711986
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Accurate characterization of CRISPR-Cas9 genome editing outcomes and mosaicism with near-perfect long reads.
Genome Medicine · 15 Sept 2026 · Journal Article
PureTarget PacBio sequencing reveals widespread genetic mosaicism with up to 18 on-target and 11 off-target variants in individual zebrafish founders.
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https://jclub.com.au/a/42754893
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Chronic exposure to diisopentyl phthalate impairs behavior, metabolism, and reproductive processes in adult female zebrafish (Danio rerio).
Environmental pollution · 15 Sept 2026 · Journal Article
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https://jclub.com.au/a/42264125
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Assessing the combined effects of bifenthrin and temperature on early life stage sturgeon.
Environmental research · 15 Sept 2026 · Journal Article
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DSTs may affect the swimming ability of marine medaka by interfering with the neurotransmitter system and calcium signaling.
Environmental pollution · 15 Sept 2026 · Journal Article
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https://jclub.com.au/a/42269747
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V-TRACE: End-to-end temporal inference and annotation ofanimal behaviors from video
bioRxiv · 14 Sept 2026 · Preprint
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Organization, development, and plasticity of the serotonergic dorsal raphe nucleus projectome
bioRxiv · 11 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.03.04.709518
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