Colorectal Cancer Treatments and Studies

Moving in New England Journal of Medicine, The Lancet, bioRxiv, Cancer Research, Gut, medRxiv, Nature Medicine and The Lancet Oncology.

Moved, week to 23 Oct 2026: 0
Papers in 60 days: 11

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Daraxonrasib in Previously Treated Metastatic Pancreatic Cancer.
New England Journal of Medicine · 22 Oct 2026 · Letter
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Daraxonrasib in Previously Treated Metastatic Pancreatic Cancer. Reply.
New England Journal of Medicine · 22 Oct 2026 · Letter
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Disease-free survival and overall survival after neoadjuvant immunotherapy in mismatch repair-deficient colon cancer in the Netherlands: results of the single-arm, multicentre, phase 2, NICHE-2 trial.
The Lancet · 21 Oct 2026 · Journal Article
Neoadjuvant nivolumab plus ipilimumab achieved 100% 3-year disease-free and 5-year overall survival in patients with locally advanced mismatch repair-deficient colon cancer.
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Redefining curative treatment for early-stage mismatch repair-deficient colon cancer.
The Lancet · 21 Oct 2026 · Journal Article
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Addendum: Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche.
Nature Medicine · 9 Oct 2026 · Journal Article
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Stromal biomarker-based framework for identifying pMMR/MSS and dMMR/MSI colorectal cancers with poor outcomes and limited benefit from immunotherapy.
Gut · 7 Oct 2026 · Journal Article
CTHRC1-expressing CAFs are linked to poor outcomes and immune resistance in both pMMR/MSS and dMMR/MSI colorectal cancers.
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Prevention of colorectal cancer through screening for advanced precancerous lesions: are blood-based tests the answer?
The lancet. Gastroenterology & hepatology · 1 Oct 2026 · Journal Article
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Global uptake of essential cancer medicines with and without complex genomic diagnostics: a retrospective observational study.
The Lancet Oncology · 25 Sept 2026 · Journal Article
Lower-GDP countries have significantly reduced uptake of essential cancer medicines, especially those requiring complex genomic diagnostics, with the lowest access observed in low-income regions.
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Discovery of Covalent Wild-Type Isocitrate Dehydrogenase 1 (IDH1) Inhibitors Targeting Cys269
bioRxiv · 25 Sept 2026 · Preprint
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Adaptive nuclear GTP synthesis promotes glioblastoma treatment resistance and is a targetable vulnerability in patients
medRxiv · 25 Sept 2026 · Preprint
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PARG Governs a PARylation-Ubiquitination Toggle that Stabilizes RAD51AP1 to Drive Homologous Recombination-Mediated Chemoresistance.
Cancer Research · 15 Sept 2026 · Journal Article
PARG stabilizes RAD51AP1 through a PARylation-ubiquitination switch, promoting homologous recombination repair and contributing to chemoresistance in gastric cancer.
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