Pulmonary Hypertension Research and Treatments

Moving in Circulation, New England Journal of Medicine, Environmental research, Frontiers in Genetics, medRxiv and Science Translational Medicine.

Moved, week to 23 Oct 2026: 0
Papers in 60 days: 8

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Targeting ZIP12-mediated Zn(2+) signaling as a treatment for pulmonary hypertension.
Science Translational Medicine · 21 Oct 2026 · Journal Article
Targeting ZIP12 with the monoclonal antibody APL-9796 reduces pulmonary hypertension symptoms in rodent models and shows promise as a therapy for PAH.
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Baseline predictors of mortality in non-idiopathic pulmonary fibrosis interstitial lung disease - A retrospective cohort study at a tertiary centre in Malaysia
medRxiv · 19 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.02.12.26346139
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Tricuspid-Valve Intervention in Heart Failure.
New England Journal of Medicine · 8 Oct 2026 · Randomized Controlled Trial
Transcatheter tricuspid-valve repair significantly improves outcomes in patients with severe tricuspid regurgitation, with a win ratio of 2.42 favoring repair at 1 year.
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Chronic exposure to aerosolized PM(2.5) in rats alters plasma protein levels and ex vivo coronary artery response to sphingosine-1-phosphate.
Environmental research · 1 Oct 2026 · Journal Article
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Identification of ion homeostasis-related genes as diagnostic biomarkers for pulmonary arterial hypertension via WGCNA and machine learning.
Frontiers in Genetics · 24 Sept 2026 · Journal Article
S1PR1, CA2, and ABCG2 are identified as potential diagnostic biomarkers for pulmonary arterial hypertension, with S1PR1 showing a protective role in endothelial cells.
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Sotatercept Improves Right Heart Mechanics Despite Reduced Myocardial Contractility in Pulmonary Arterial Hypertension: A Prospective Exercise Hemodynamic Study.
Circulation · 22 Sept 2026 · Journal Article
Sotatercept reduces right ventricular contractility by 24 weeks in pulmonary arterial hypertension patients but maintains RV-PA coupling and improves overall right heart mechanics.
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https://jclub.com.au/a/42770225
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Pulmonary Denervation for Heart Failure-Related Pulmonary Hypertension.
New England Journal of Medicine · 30 Aug 2026 · Journal Article
Pulmonary-artery denervation reduces clinical worsening by nearly 50% in patients with heart failure-related pulmonary hypertension compared to medical therapy alone.
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Endothelial SHMT2 Drives Pulmonary Vascular Remodeling Through Noncanonical Pathway in Pulmonary Hypertension.
Circulation · 25 Aug 2026 · Journal Article
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