Adaptamers, a compact RNA switch, enable precise, reversible control of transgene expression via small-molecule-dependent ADAR-mediated RNA editing in vivo.
RNA Interference and Gene Delivery
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Human Argonaute 2 fused to a C-to-U deaminase achieves 1.9-fold higher targeted RNA editing in HEK293T cells compared to Cas13-based editors.
- Open access
Meta-analysis of melanoma miRNome reveals 24 diagnostic and 23 prognostic miRNA signatures that regulate metabolic plasticity and stress resistance in melanoma progression.
- Open access
- 2 cites
GlycoRNAs, a novel class of small noncoding RNAs covalently modified with N-glycans, reside on the cell surface and reshape RNA regulatory understanding.
- Open access
Synthetic pH-responsive membranolytic peptide aMP C16-CA50 induces immunogenic cell death in tumor cells, enhancing immune checkpoint blockade therapy in mice.
Cyanophage-encoded thioredoxin and virulence enhancer genes significantly boost phage fitness and infection success in marine Synechococcus, with thioredoxin increasing replication and cve enhancing virulence.
- Open access
- 2 cites
CRISPR RNP-mediated genome editing achieves transgene-free modifications in woody plants but faces significant delivery and regeneration challenges, especially in species like bamboo.
- Open access
- 21 cites
Novel in vivo delivery systems and immune-silent mRNA formulations are advancing mRNA therapeutics 2.0, enabling repeated administration and targeted organ delivery.
Proteolytic control of CRISPR-Cas systems achieves precise, tunable gene expression with reduced variability, enabling improved gene therapy for dosage-sensitive disorders.
- Open access
- 2 cites
DNA oligonucleotides encoding suppressor tRNA induce PTC readthrough in cultured cells without additional promoters.
- Open access
Nanomaterials significantly enhance phage stability, detection sensitivity, targeted delivery, and antibacterial efficacy, advancing phage therapy applications.
- Open access
AptViralDB provides a comprehensive, manually curated database of 1,768 experimentally validated antiviral aptamers targeting 40 viral species and 104 molecular targets.
- Open access
mRNA-encoded CD19-targeting T cell engager achieves complete B cell depletion and durable platelet recovery in refractory immune thrombocytopenia with minimal safety concerns.
- Open access
Aptamer-guided delivery of miR-126 significantly reduces glioblastoma stem-like cell invasion and tumor progression in mouse models.
- Open access
rAAV-mediated delivery of multiple miRNAs targeting MAPK signaling suppresses laser-induced choroidal neovascularization in mice by reducing CNV leakage and angiogenesis.
- Open access
A BAC-based non-infectious SARS-CoV-2 replicon identified the M gene as a promising antisense target with an EC50 of 6.3 nM for antiviral development.
- Open access
Segmented poly(A) tails with microRNA target sites enable tissue-specific regulation of mRNA expression, with suppression observed in non-target cells in vitro and in vivo.
- Open access
Multi-cycle reagent recycling in in vitro transcription and purification reduces raw-material costs by over twofold while maintaining RNA quality over five cycles.
- Open access
Codon-dependent translation of N1-ethylpseudouridine-modified mRNA reduces innate immunity while maintaining vaccine efficacy.
- Open access
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Topics moving, week to 22 Oct 2026
- Single-cell and spatial transcriptomics6
- Neuroinflammation and Neurodegeneration Mechanisms5
- Cancer Immunotherapy and Biomarkers5
- Gut microbiota and health5
- Cancer Genomics and Diagnostics4
- Bacteriophages and microbial interactions4
- CAR-T cell therapy research3
- Lung Cancer Treatments and Mutations3
- Liver Disease Diagnosis and Treatment3
- Dementia and Cognitive Impairment Research3