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Nutrition and Health in Aging

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Moved, week to 22 Oct 2026: 1
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Lung Tumors Hack Nervous System to Drive Cachexia.
Cancer Discovery · 29 July 2026 · News
Lung tumors in mice can cause cachexia by directly communicating with neurons to alter eating behavior, with some tumors having this capability.
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Plasma proteomics identifies an IL-6 -associated SAA axis linked to muscle wasting and survival in patients with cancer cachexia
bioRxiv · 21 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.06.11.730788
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A health-system-scale, episode-resolved multimodal atlas of cancer cachexia.
Nature Medicine · 12 Oct 2026 · Journal Article
Longitudinal clinicogenomic data from over 52,000 cancer patients reveal cachectic weight loss episodes cluster near disease progression and are linked to worse outcomes across cancer types.
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Roseburia inulinivorans increases muscle strength.
Gut · 7 Oct 2026 · Journal Article
Roseburia inulinivorans is linked to increased muscle strength and may serve as a probiotic for age-related muscle-wasting conditions.
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Nutrition and Body Composition: Missing Outcomes in Appetite- and Weight-Modifying Therapies for Individuals With Inflammatory Bowel Disease.
Gastroenterology · 1 Oct 2026 · Journal Article
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Exploring the potential targets and possible mechanisms of Shenqi Fuzheng Injection in the treatment of cancer-associated muscle wasting based on network pharmacology.
Frontiers in Genetics · 1 Oct 2026 · Journal Article
Shenqi Fuzheng Injection may target Caspase-3 and Caspase-8 to reduce apoptosis in cancer-associated muscle wasting, with key components showing strong binding affinity.
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Bridging bone and muscle: ontology-driven prioritization of candidate genes at the osteoporosis-sarcopenia interface by gene ontology reverse lookup.
Frontiers in Genetics · 25 Sept 2026 · Journal Article
GOReverseLookup identified 37 candidate genes at the osteoporosis-sarcopenia interface, including less-characterized genes like RBCK1, LGALS9, ZBTB7A, and RPS3.
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MRI-informed active surveillance outcomes and dietary fibre acceptability: the Aberdeen experience
medRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.24.26363863
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Echo intensity is not an accurate surrogate marker of intramuscular fat and fibrosis: A systematic review with meta-analyses
medRxiv · 24 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.19.26363379
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Circulating Proteins as Predictors of Improvement in Physical Function in Hospitalized Older Adults with Geriatric Syndromes: Findings from the REHAB-HF Trial
medRxiv · 23 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.22.26363692
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Pathophysiological remodeling of the skeletal muscle microenvironment in patients with lung cancer
bioRxiv · 22 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.11.19.689342
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Spatiotemporal metabolic networks in a preclinical model of pancreatic cancer and associated cachexia.
Nature Communications · 18 Sept 2026 · Journal Article
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Gastric Residual Volume Assessment in Critically Ill Children: Research Summary.
JAMA · 8 Sept 2026 · Journal Article
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WITHDRAWN: Combined triglyceride-glucose and frailty index (TyGFI) and risk of endometrial cancer in U.S. women aged >=45: NHANES 2011-2018 analysis integrating data engineering and machine learning with logistic modeling
medRxiv · 8 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.07.02.26357105
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Strengthening muscle for healthy ageing: innovative treatments for sarcopenia.
Nature Reviews Drug Discovery · 7 Sept 2026 · Review
Pharmacological strategies targeting multiple cellular pathways show promise in combating sarcopenia, a major cause of frailty in aging populations, with recent clinical trials indicating progress.
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Efficacy and safety of zalfermin co-administered with semaglutide in participants with fibrosis and cirrhosis due to metabolic dysfunction-associated steatohepatitis: a phase 2, dose-ranging, double-blind, randomised controlled trial.
The lancet. Gastroenterology & hepatology · 1 Sept 2026 · Randomized Controlled Trial
Semaglutide 2·4 mg significantly improved liver fibrosis without worsening steatohepatitis in patients with fibrosis and cirrhosis, unlike the zalfermin combination.
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Consistent MYORG Downregulation in DMD and LGMD: Transcriptomic and Proteomic Evidence Supporting Deoxygalactonojirimycin Repurposing
bioRxiv · 29 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.06.17.732878
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Mitochondrial Permeability Transition in Skeletal Muscle Phenocopies Muscle Alterations seen in Cancer Cachexia and other Wasting Conditions
bioRxiv · 26 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.02.12.705530
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Association between sarcopenia and the risk of diabetic cardiomyopathy in patients with type 2 diabetes mellitus: a single-center retrospective cohort study.
Frontiers in Genetics · 25 Aug 2026 · Journal Article
Sarcopenia independently increases the risk of diabetic cardiomyopathy by 2.25 times in patients with type 2 diabetes mellitus.
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Replication of protein associations is not external validation of a fixed mortality score.
Gut · 24 Aug 2026 · Letter
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https://jclub.com.au/a/42637527
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Mortality prediction by rate of skeletal muscle loss in cirrhosis: some methodological considerations.
Gut · 24 Aug 2026 · Letter
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