Pharmacogenetics and Drug Metabolism

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Discovery of noncanonical cytochrome P450 enzymes in nature.
Nature Chemical Biology · 1 Oct 2026 · Journal Article
Twenty noncanonical cytochrome P450 families lacking a conserved cysteine ligand are identified in diverse microbial genomes, including the first native selenocysteine-ligated CYP.
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Personalised medicine in oncology: inequality aversion in a fast-moving field.
The Lancet Oncology · 1 Oct 2026 · Journal Article
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Improvement opportunities for P450 biocatalytic applications in the pharmaceutical industry.
Biotechnology advances · 1 Oct 2026 · Review
Enhancing P450 enzyme components with greater degrees of freedom is key to expanding biocatalytic opportunities in pharmaceutical applications.
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Non-canonical cytochrome P450 enzymes expand the diversity of bacterial hemoproteins.
Nature Chemical Biology · 1 Oct 2026 · Journal Article
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Design, simulate, refine: simulation-guided clinical trials for accelerated drug development.
Nature Reviews Drug Discovery · 1 Oct 2026 · Review
Simulation-guided design enhances complex clinical trial planning by evaluating operating characteristics and refining protocols for accelerated drug development.
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https://jclub.com.au/a/42443403
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Decomposing population differences in type 2 diabetes through a high-resolution GWAS of ~600,000 individuals with East Asian ancestry.
Communications Biology · 30 Sept 2026 · Journal Article
A high-resolution GWAS of nearly 600,000 East Asians identified 196 loci for T2D, including three novel loci, with 74% shared causal signals across populations.
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https://jclub.com.au/a/42816531
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AetherXeno: an allele-resolved receptor-occupancy atlas for regulatory pharmacogenomics
bioRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.20.752952
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The urinary tract commensal Peptoniphilus spp. encodes a novel 17β-hydroxysteroid dehydrogenase.
Applied and environmental microbiology · 23 Sept 2026 · Journal Article
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https://jclub.com.au/a/42657876
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Gut bacteria convert cortisol into a distinct hostsignalling molecule
bioRxiv · 17 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2020.06.12.149468
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Associations of urinary benzothiazole and its derivatives with hypertension and underlying metabolic perturbations.
Environmental pollution · 15 Sept 2026 · Journal Article
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