Circadian rhythm and melatonin
Moving in bioRxiv, Plant Physiology and Biochemistry, Environmental research, eLife, Cell Reports, medRxiv, Environmental pollution and Nature.
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Latest in Circadian rhythm and melatonin
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Photo-downregulation of SIRT4 in aged mice increases H3K9ac levels by activating fatty acid metabolism, thereby mitigating cellular aging.
- Open access
Lack of the circadian photoreceptor cryptochrome (CRY) leads to increased sleep under short winter-like days in fruit flies, resembling winter hypersomnolence in SAD.
- Open access
Deletion of tyrosine hydroxylase in approximately 25% of substantia nigra dopamine neurons significantly suppresses food-anticipatory locomotion in mice.
Genetic variation in core circadian genes and circadian misalignment are linked to human disease risk, progression, and therapeutic response.
Heat exposure causes distinct diurnal renal responses, with daytime exposure affecting blood markers and nighttime exposure elevating urinary stress biomarkers, highlighting time-dependent kidney vulnerability.
Long-term exposure to short-duration cold and heat extremes is linked to increased hypertension risk in a Chinese cohort, with hazard ratios up to 1.06.
Long-range Sst-Chodl inhibitory neurons in the neocortex actively promote sleep and synchronized cortical activity, especially during low-arousal states, in mice.
- Open access
Melatonin enhances tomato tolerance to combined salinity and drought stress, increasing dry weight by approximately 37% and reducing MDA by nearly 40% under stress conditions.
- Open access
Circadian and sleep disruptions in Drosophila melanogaster cause significant metabolic dysregulation, with mutant and constant darkness conditions showing impaired redox homeostasis.
- Open access
- 1 cites
The pulvinar primarily relays signals from V1 to V2 in macaques, with V1 activity leading pulvinar and pulvinar leading V2, supporting a feedforward communication role.
- Open access
Tissue-wide Erk oscillations synchronize zebrafish notochord segmentation, controlling the formation of mineralizing segments with a periodic rhythm.
- Open access
- 2 cites
Caloric restriction enhances circadian metabolic regulation and improves glucose and fatty acid metabolism compared to fasting-refeeding cycles, with a significant impact on metabolic health.
- Open access
Lactobacillus plantarum and its metabolite indole-3-lactic acid restore skin barrier function by modulating the clock-ferroptosis axis in psoriasis.
- Open access
Sex-specific biological aging clocks across organs reveal distinct genetic, molecular, and clinical aging signatures in males and females.
- Open access
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Topics moving, week to 23 Oct 2026
- Single-cell and spatial transcriptomics6
- Neuroinflammation and Neurodegeneration Mechanisms5
- Bacteriophages and microbial interactions5
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- Alzheimer's disease research and treatments3
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