Cardiac electrophysiology and arrhythmias

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LMNA Haploinsufficiency in Human iPSC-Derived Cardiac Organoids Reveals Early Fibrotic Signaling as a Therapeutically Targetable Process
bioRxiv · 22 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.03.25.714182
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Interpreting variants associated with congenital heart disease with a regulatory map of the human fetal heart
medRxiv · 17 Oct 2026 · Preprint
Gene regulation map of the human fetal heart reveals that both rare coding and common noncoding variants associated with CHD converge on valvular interstitial cells (VICs).
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https://jclub.com.au/a/10.1101/2024.11.20.24317557
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A phase 2 trial of daratumumab monotherapy for patients with newly diagnosed cardiac stage IIIb AL amyloidosis.
Blood · 15 Oct 2026 · Clinical Trial, Phase II
Daratumumab monotherapy achieves a 75% hematologic response rate and a 65% 6-month overall survival in patients with stage IIIB AL amyloidosis.
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https://jclub.com.au/a/42296025
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L-type channel voltage-dependent facilitation results from asymmetric π-H and π-π quadrangle interactions at DI-DII domains
bioRxiv · 5 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.01.23.701029
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Generation of two human induced pluripotent stem cell lines from patients with hypokalemic periodic paralysis.
Stem cell research · 1 Oct 2026 · Journal Article
Two human iPSC lines from HypoPP patients carrying the CACNA1S c.1583G>A (p.Arg528His) mutation were generated and characterized for research use.
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https://jclub.com.au/a/42759100
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Generation of an induced pluripotent stem cell line, JHUi010-A, from an arrhythmogenic cardiomyopathy patient harboring pathogenic DSG2 variant c.2358delA.
Stem cell research · 1 Oct 2026 · Journal Article
A human induced pluripotent stem cell line from an arrhythmogenic cardiomyopathy patient with DSG2 c.2358delA variant was successfully generated and characterized.
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https://jclub.com.au/a/42762668
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Generation of an induced pluripotent stem cell line from a long QT syndrome type 1 patient carrying the KCNQ1 c.343G > A p.(E115K) variant.
Stem cell research · 1 Oct 2026 · Journal Article
An induced pluripotent stem cell line from a long QT syndrome type 1 patient with the KCNQ1 c.343G > A p.(E115K) variant was successfully generated, maintaining normal cellular characteristics.
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https://jclub.com.au/a/42763977
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Multimodal Integration of Ambulatory ECG and Clinical Features for Sudden Cardiac Death and Pump Failure Death Prediction
medRxiv · 30 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.04.21.26351421
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Endogenous subthreshold noise and PIP2 tune diastolic coherence across the intact sinoatrial node through stochastic resonance
bioRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.18.752780
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Computational Framework for Identifying Ion Channel Mutation-Compensating Interventions
bioRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.20.753002
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Monte Carlo modeling of the formation and organization of ion channel clustering.
PLOS Computational Biology · 17 Sept 2026 · Journal Article
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https://jclub.com.au/a/42752396
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WNK-SPAK/OSR1 signaling pathway facilitates ictal activity via reduced neuronal chloride extrusion rate
bioRxiv · 14 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.06.10.731153
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Image-based deep learning for emergency electrocardiogram classification
medRxiv · 11 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.06.18.26355968
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Mathematical Modeling of Late-Stage LC Aggregation and Cardiac Injury Following Establishment of a Pathogenic Plasma-Cell Clone
bioRxiv · 6 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.10.30.685705
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Innervated human cardiac muscle model reveals sympathetic drivers of KCNH2-associated arrhythmias.
Nature Communications · 2 Sept 2026 · Journal Article
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https://jclub.com.au/a/42686760
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Establishment of CRISPR/Cas9-edited LEMD2 knock-in (UKWCHFi001-B-1) and knock-out (UKWCHFi001-B-2) iPSC lines to investigate the mechanisms of LEMD2-associated cardiomyopathy.
Stem cell research · 1 Sept 2026 · Journal Article
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https://jclub.com.au/a/42385351
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Generation of an arrhythmogenic right ventricular cardiomyopathy-patient-derived iPS cell line with PKP2 and AKAP9 mutation (MUNIi022-A).
Stem cell research · 1 Sept 2026 · Journal Article
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https://jclub.com.au/a/42398419
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Cardiac organoids bridge translational gaps in 3R-compliant safety testing.
Stem cell research · 1 Sept 2026 · Review
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https://jclub.com.au/a/42364506
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Generation of human induced pluripotent stem cell lines from relatives of an unexplained sudden cardiac death victim carrying a Brugada Syndrome-associated, SCN5A c.287 T > C, variant.
Stem cell research · 1 Sept 2026 · Journal Article
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https://jclub.com.au/a/42574958
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Generation of WTC11 CLYBL-CAG_GCaMP8f cell line for fast and sensitive calcium tracking.
Stem cell research · 1 Sept 2026 · Journal Article
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https://jclub.com.au/a/42258895
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Heterogeneous Treatment Effects in HFpEF: Distinguishing Drug-Specific Response from Prognostic Phenotypes Across Randomized Trials
medRxiv · 28 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.07.06.26357251
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Characterization of an early-diverging KCNE potassium-channel auxiliary subunit in the jawless vertebrate lamprey.
eLife · 26 Aug 2026 · Journal Article
Lamprey KCNE0, an early-diverging KCNE family member, induces constitutive KCNQ1 activity, highlighting its unique role in vertebrate ion channel regulation.
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