Parkinson's Disease Mechanisms and Treatments

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Network analysis of α-synuclein pathology progression reveals p21-activated kinases as regulators of vulnerability
bioRxiv · 21 Oct 2026 · Preprint
Group II p21-activated kinases (PAKs) are identified as regulators of regional vulnerability to α-synuclein pathology in Parkinson's disease models.
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https://jclub.com.au/a/10.1101/2024.10.22.619411
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Dysregulated cholesterol trafficking through ABCA1 drives neurodegeneration in Parkinson's disease.
Nature Neuroscience · 20 Oct 2026 · Journal Article
Elevated ABCA1 expression in the substantia nigra is linked to cholesterol overload and neurodegeneration in Parkinson's disease mouse models and postmortem brains.
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https://jclub.com.au/a/42901980
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PD-RISK Index: Piloting an unsupervised toolkit to identify adults with Parkinson disease
medRxiv · 19 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.04.30.26352172
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Antihypertensive medications and risk of Parkinson's Disease: multi-cohort trial emulation and transcriptomic analyses
medRxiv · 15 Oct 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.05.20.25327943
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Generation of a CRISPR/Cas9-corrected isogenic control iPSC line (NIMHi001-A-1) from a Parkinson's disease Patient-Derived iPSC line carrying the LRRK2 I1371V mutation.
Stem cell research · 9 Oct 2026 · Journal Article
CRISPR/Cas9 editing successfully corrected the LRRK2 I1371V mutation in a Parkinson's disease patient-derived iPSC line, creating an isogenic control line with confirmed genetic integrity.
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https://jclub.com.au/a/42874242
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"Plasma Membrane Calcium ATPase Downregulation in Dopaminergic Neurons Induces Presynaptic Dysfunction and Neuronal Vulnerability In Vivo and In Vitro"
bioRxiv · 8 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.04.30.721667
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Exacerbation of neurodegeneration by a metabolically engineered bacterium in a mouse model of tauopathy
bioRxiv · 8 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.28.755025
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Integrating dorsolateral prefrontal cortex multi-omics and GWAS summary data enhances gene-mapping of Parkinson's disease
medRxiv · 5 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.05.23.26353951
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Local ROS and inefficient autophagosome formation limit Optineurin-mediated mitophagy in neurons
bioRxiv · 3 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.01.16.700014
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Disease-specific tau polymorphs are associated with unique protein networks across proteinopathies.
EMBO Journal · 1 Oct 2026 · Journal Article
Distinct tau polymorphs in Alzheimer’s disease, PSP, and DLB associate with unique protein interaction networks, with 493 high-confidence interactors identified.
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https://jclub.com.au/a/42613429
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Familial Parkinson's Disease Mutations Converge on Alternative Splicing Programs Linked to Lysosomal, Autophagic and Vesicle Trafficking Pathways
bioRxiv · 1 Oct 2026 · Preprint
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https://jclub.com.au/a/10.1101/2024.02.28.582420
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Leveraging structurally-informed bioorthogonal conjugation for alpha synuclein fibril surveillance
bioRxiv · 30 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.09.12.675751
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Validity Gates Expose Limits of Longitudinal Multimodal Parkinson Disease Prediction
medRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.23.26363849
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State-selective inhibition of alpha-synuclein aggregation by de novo oligomer-binding proteins
bioRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.07.13.738012
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Elevated phosphorylated α-synuclein and phosphorylated tau in Lrrk2 p.G2019S-mutant mice following influenza A pneumonitis
bioRxiv · 19 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.07.31.667659
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Challenging selective vulnerability in Parkinson's disease: a systematic review and meta-analysis
bioRxiv · 19 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.05.13.724902
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Sex-stratified analysis of the potential association between PGLYRP2 rs892145 variant and Parkinson's disease across diverse ancestral populations
medRxiv · 15 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.07.23.25331993
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Clinical outcomes with chronic adaptive versus conventional DBS in Parkinson's disease: A pilot randomized crossover trial
medRxiv · 11 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.09.07.25335282
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Dystrophic changes of nigrostriatal axons harboring a Synj1 Parkinson mutation suggest catastrophic failure of endocytic mechanisms
bioRxiv · 10 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.06.24.733515
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The modern utility of awake deep brain stimulation surgery
medRxiv · 9 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.09.25.25336654
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GLP-1 receptor agonist use is associated with shorter survival in patients with amyotrophic lateral sclerosis and diabetes mellitus
medRxiv · 6 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.05.05.25326993
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Vps35 p.D620N causes Lrrk2 kinase hyperactivity, chronic microglial activation and inflammation
bioRxiv · 3 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.03.09.710482
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Dermal Phospho-Alpha-Synuclein Among Individuals With and Without Cerebrospinal Fluid Aggregated Alpha-Synuclein
medRxiv · 2 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2025.12.17.25342090
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The Parkinson's disease-linked G2019S mutation of LRRK2 increases NADPH oxidase-2 activity in neutrophils for superior control of bacterial infections.
Cellular & molecular immunology · 1 Sept 2026 · Journal Article
The G2019S mutation in LRRK2 enhances NADPH oxidase-2 activity in neutrophils, improving bacterial infection control in mice by 2- to 3-fold.
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https://jclub.com.au/a/42463806
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Gender-associated differences in serum metabolite profiles among patients with Parkinson's Disease
medRxiv · 1 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.10.30.25339159
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Generation of an induced pluripotent stem cell line (NIMHi032-A) from a progressive supranuclear Palsy-Richardson's syndrome patient of Indian ethnicity.
Stem cell research · 1 Sept 2026 · Journal Article
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https://jclub.com.au/a/42314572
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Generation of an induced pluripotent stem cell line (NIMHi28-A) from a parkinsonian-type multiple system atrophy patient of Indian origin.
Stem cell research · 1 Sept 2026 · Journal Article
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https://jclub.com.au/a/42296842
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Meta-analysis of glucose metabolism across Alzheimer's, Parkinson's and ALS reveals distinct patterns of cortical hypometabolism versus subcortical hypermetabolism with disease-specific spatial signatures
medRxiv · 31 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.04.07.26350339
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ClC-7 links PIKfyve inhibition to Rab-dependent LRRK2 activity at lysosomes
bioRxiv · 29 Aug 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.11.19.689251
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PD GENEration: An International Parkinson's Disease Genetic Research Study
medRxiv · 28 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.05.20.26353696
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