MicroRNA in disease regulation

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LIN28B is a post-transcriptional regulator of Wnt signalling in myeloid leukemia cells and dual targeting promotes cytotoxicity
bioRxiv · 19 Oct 2026 · Preprint
LIN28B interacts with β-catenin and regulates Wnt signaling through post-transcriptional modulation in myeloid leukemia cells.
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https://jclub.com.au/a/10.64898/2026.01.25.698240
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Enhancer-AAVs allow genetic access to oligodendrocytes and diverse populations of astrocytes across species
bioRxiv · 8 Oct 2026 · Preprint
Enhancer-AAVs achieve over 95% cell type specificity in targeting oligodendrocytes and astrocytes across species, enabling detailed glial cell studies.
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https://jclub.com.au/a/10.1101/2023.09.20.558718
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A comprehensive resource for studying microRNA evolution and microRNA-mediated development and whole-body regeneration in the acoel worm Hofstenia miamia
bioRxiv · 8 Oct 2026 · Preprint
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https://jclub.com.au/a/10.1101/2024.12.01.626237
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Meta-analysis of the melanoma miRNome identifies consensus signatures of progression and prognosis regulating metabolic plasticity and stress resistance
bioRxiv · 8 Oct 2026 · Preprint
Meta-analysis of melanoma miRNome reveals 24 diagnostic and 23 prognostic miRNA signatures that regulate metabolic plasticity and stress resistance in melanoma progression.
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https://jclub.com.au/a/10.1101/2023.10.20.563284
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Developmental small RNA transcriptomics reveals divergent evolution of the conserved microRNA miR-100 and the let-7-complex in nematodes
bioRxiv · 7 Oct 2026 · Preprint
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https://jclub.com.au/a/10.1101/2024.07.19.604269
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microRNAs control temporal patterning of the vertebrate nervous system
bioRxiv · 2 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.10.02.755877
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Bioinformatic prediction, qCLASH, and AlphaFold3 reveal non-overlapping layers of the miR-214-3p-mRNA interactome.
Frontiers in Genetics · 30 Sept 2026 · Journal Article
Bioinformatic prediction, qCLASH, and AlphaFold3 reveal distinct, non-overlapping layers of the miR-214-3p-mRNA interactome in mouse lung tissue.
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https://jclub.com.au/a/42872190
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Translation of a small upstream open reading frame functions as a rheostat for the regulation of lin-41 by the Let-7 microRNA in Caenorhabditis elegans
bioRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.22.750518
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MATR3 is essential for oocyte growth and maturation quality through a dual molecular mechanism.
eLife · 21 Sept 2026 · Journal Article
MATR3 is crucial for oocyte growth and maturation, with its absence causing growth restriction and infertility in mice, highlighting its essential dual role.
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https://jclub.com.au/a/42765984
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Aptamer-guided delivery of miR-126 suppresses glioblastoma stem-like cell invasion and tumor progression.
Molecular therapy. Nucleic acids · 17 Sept 2026 · Journal Article
Aptamer-guided delivery of miR-126 significantly reduces glioblastoma stem-like cell invasion and tumor progression in mouse models.
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https://jclub.com.au/a/42840422
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A deep generative decoder predicts microRNA expression from bulk and single-cell mRNA profiles
bioRxiv · 10 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.05.29.727918
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Long non-coding RNA-3'UTR interactions coordinate GABA signaling in the brain
bioRxiv · 10 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.09.05.674572
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Control of timing and directionality during neurodifferentiation of human induced Pluripotent Stem Cells (iPSC) via miRNA-mediated feedback and feedforward loops.
bioRxiv · 4 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2023.10.16.562489
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Modified self-amplifying RNA mediates robust and prolonged gene expression in the mouse and ex vivo human brain
bioRxiv · 1 Sept 2026 · Preprint
Modified hm5C self-amplifying RNA enables over five weeks of sustained gene expression in mouse brain cells and more than 76 days in human brain slices.
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https://jclub.com.au/a/10.1101/2025.10.30.685635
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Establishment of a cBSA-mediated miRNA delivery system in Camellia sinensis and functional validation of the Cs-miR163/CsSK1 module in cold stress response.
Plant Physiology and Biochemistry · 1 Sept 2026 · Journal Article
A cBSA-mediated miRNA delivery system was developed in Camellia sinensis, enabling efficient in vivo functional validation of miRNA-target modules, exemplified by a 72% gene silencing.
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https://jclub.com.au/a/42731281
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Detecting and quantifying circular RNAs in terabyte-scale RNA-seq datasets with CIRI3.
Nature Biotechnology · 1 Sept 2026 · Journal Article
CIRI3 detects and quantifies circRNAs in terabyte-scale RNA-seq datasets with ten times greater speed and higher accuracy than existing tools.
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https://jclub.com.au/a/41034498
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The miRNA-ROS interactome: Orchestrating plant resilience to environmental fluxes.
Plant Physiology and Biochemistry · 1 Sept 2026 · Review
The miRNA-ROS interactome is a conserved, multi-layered regulatory network crucial for plant stress resilience, coordinating ROS homeostasis across cellular compartments.
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https://jclub.com.au/a/42743829
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Generation of miR-141/200c conditional knockout mice from knockout-first, reporter-tagged parent and functional validation of the floxed allele
bioRxiv · 27 Aug 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.09.02.673774
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Emerging strategies and innovations in circular RNA synthesis.
Molecular therapy. Nucleic acids · 26 Aug 2026 · Review
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https://jclub.com.au/a/42780376
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