From Mendel's peas to polygenic prediction.

Polygenic risk scores (PRSs) have evolved from Mendel's and Fisher's early work and are now ready for implementation in selected conditions within genomic learning health systems.

• Why it matters: PRSs are important because they provide quantitative estimates of disease susceptibility based on genome-wide genetic variants, addressing a key gap in personalized medicine.
• What they did: The author reviews the historical development of PRSs and discusses their potential for integration into health systems that adapt as new evidence emerges.
• The result: This work suggests that PRSs can now be effectively implemented in clinical settings, enabling more precise disease risk prediction and supporting adaptive, evidence-based healthcare.