Manc-COJO enhances detection of independent associations in multiancestry GWAS, outperforming GCTA-COJO with over 120-fold faster processing and improved accuracy.
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- 1 cites
Genetic Associations and Epidemiology
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Variant effects in MPRAs are highly dependent on their position within the construct, with expression change magnitudes varying substantially based on placement.
- Open access
Manc-COJO enhances detection of independent associations in multiancestry GWAS, outperforming GCTA-COJO with over 120-fold faster processing and improved accuracy.
- Open access
- 1 cites
GISMO and GISMO-mis, two mammalian constraint metrics, strongly correlate with human gene essentiality and identify critical genes missed by existing methods, especially short genes.
- Open access
Plasma protein quantitative trait loci (pQTL)-supported target-indication pairs are 4.4 times more likely to progress from Phase I to launch than other genetic evidence in drug development.
- Open access
DNACipher predicts the effects of genetic variants across 38,582 cell type/assay combinations, over six times more contexts than previous models, enabling comprehensive variant impact analysis.
- Open access
- 2 cites
Gene regulation map of the human fetal heart reveals that both rare coding and common noncoding variants associated with CHD converge on valvular interstitial cells (VICs).
- Open access
- 15 cites
Genetic variants related to homocysteine and folate metabolism are significantly associated with edematous severe childhood malnutrition, with a z-score of 3.2.
- Open access
VampW, a Bayesian method, reduces false discoveries and improves disease onset prediction by jointly modeling correlated omics features in time-to-event data.
- Open access
Imputation of fluid intelligence scores increases genetic associations from 390 to 550 and identifies 26 neurodevelopmental genes, including 8 novel candidates.
- Open access
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