An ALLO-1-associated network links mitochondrial quality control to functional recovery in structurally compromised muscle.

ALLO-1 regulates mitochondrial stress responses and enables muscle functional recovery before structural repair in C. elegans muscle.

• Why it matters: Understanding how muscle function recovers despite persistent structural disorganization can reveal new targets for muscle repair strategies. The mechanisms behind early functional recovery are not well understood, especially in relation to mitochondrial quality control.
• What they did: Using a temperature-sensitive C. elegans model of UNC-45 dysfunction, the study identified ALLO-1, a selective-autophagy receptor, and its associated network involving IKKE-1, SIP-1, DIM-1, and CAR-1, through proteomic and functional analyses.
• The result: Loss of ALLO-1 or its factors delayed recovery and disrupted mitochondrial homeostasis, while muscle-specific ALLO-1a restoration improved recovery and mitochondrial network integrity, highlighting ALLO-1’s role in mitochondrial stress adaptation and early muscle function recovery.