Whole genome duplication through mitotic slippage causes nuclear instability.

Mitotic slippage-induced whole-genome duplication causes widespread nuclear instability in polyploid cells.

• Why it matters: Understanding how different routes to WGD affect nuclear stability is crucial because nuclear abnormalities can influence cell function and disease progression.
• What they did: The study compared pathways of WGD under physiological and non-physiological conditions, focusing on mitotic slippage, cytokinesis failure, and endoreplication, and observed nuclear features.
• The result: Only mitotic slippage resulted in highly variable nuclear deformations and increased nuclear softness, leading to nuclear reorganization, with similar instability seen in physiological megakaryocytes, highlighting the route's impact on nuclear architecture.