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A single-cell atlas of large B cell lymphomas reveals distinct malignant archetypes predictive of clinical outcomes.
Blood · · Journal Article · Open access
Baaklini, Sarrabay + more
Abstract ↗AI summary
The abstract is read at the publisher; the summary is JClub's.
Five conserved malignant B cell archetypes, including a quiescent memory B cell-like type, predict clinical outcomes in large B cell lymphomas, with Archetype 4 linked to poor survival.
- Why it matters: Heterogeneity in LBCLs causes variable treatment responses and high relapse rates, underscoring the need for better prognostic markers and personalized therapies.
- What they did: Single-cell RNA-seq, BCR-seq, and TCR-seq were performed on 63 LBCL biopsies, revealing five archetypes of malignant B cells that co-occur within tumors and vary among patients.
- The result: High levels of Archetype 4, marked by memory B cell features and quiescence, were associated with worse event-free survival, enabling improved patient stratification for targeted treatment.
The findingWhy it mattersWhat they didThe result
- Open access