Fc-optimized GITR antibody enhances a CD4 T cell-dendritic cell crosstalk to promote antitumor immunity.

Fc-optimized human anti-GITR antibody enhances antitumor efficacy by promoting CD4 T cell-dendritic cell crosstalk in humanized mice.

• Why it matters: Understanding how Fc interactions influence anti-GITR antibody activity is crucial for improving cancer immunotherapy strategies that activate effector T cells and deplete regulatory T cells.
• What they did: Researchers engineered Fc domains of human anti-GITR mAbs to optimize FcγR engagement and tested these in humanized mice, identifying an Fc-optimized IgG scaffold that boosts antitumor responses.
• The result: The Fc-optimized antibody enhances regulatory T cell depletion, promotes mutual activation of CD4+ T cells and dendritic cells, and increases CD8+ T cell activity, suggesting improved therapeutic potential.