Multiscale evolution of the 3D genome.

Genome architecture can evolve rapidly in cancer cells due to mutations and epigenetic changes, highlighting dynamic micro-scale structural shifts.

• Why it matters: Understanding how genome organization changes across different biological scales is crucial for revealing its role in development, disease, and evolution, yet a comprehensive framework is lacking.
• What they did: The review synthesizes research on 3D genome evolution at cellular, species, and higher phylogenetic levels, emphasizing local genomic alterations and convergent higher-order features.
• The result: Findings suggest that genome architectures exhibit rapid micro-scale evolution in cancer and diverse macro-scale patterns across species, with recurrent features reflecting shared functional constraints.