Syntaxin11 deficiency inhibits CRAC channel priming, reducing calcium entry and gene expression in T lymphocytes independently of membrane trafficking, with implications for immune disorders.
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Calcium signaling and nucleotide metabolism
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PIKfyve regulates ER morphology and dynamics by modulating lysosome-ER contacts, with its inhibition causing less reticulated ER and impaired motility.
Cas12a chRDNA genome editing achieves near-complete target gene disruption with high specificity and no detectable off-target effects in vivo.
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