Psychedelics and Drug Studies

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Investigating molecular and hemodynamic effects of LSD in the human brain.
Nature Neuroscience · 12 Oct 2026 · Journal Article
LSD occupies 5-HT2AR with high affinity and increases global cerebral blood flow and internal carotid artery flow in humans.
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Multimodal autonomic arousal tracks dose-dependent affective dynamics during the acute effects of DMT
bioRxiv · 7 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.04.30.721872
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Embeddedness under psilocybin.
Nature Neuroscience · 1 Oct 2026 · Journal Article
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Psilocybin and Contrasting Musical Compositions: Effects on Music-Evoked Emotional Responses in Healthy Adults
medRxiv · 23 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.09.26362648
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Mechanistic Basis for 5-HT(2A)R Over 5-HT(2B)R Activation.
Nature Communications · 17 Sept 2026 · Journal Article
Selective activation of 5-HT(2A) receptors over 5-HT(2B) receptors was achieved with derivatives showing high specificity, confirmed by cryo-EM structures.
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Structure-based design of subtype-selective psychedelic analogs.
Nature Communications · 17 Sept 2026 · Journal Article
Cryo-EM structures reveal key residue differences enabling design of 5-HT 2A receptor-selective psychedelics, avoiding 5-HT 2B receptor activation.
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A neuro-computational approximation of the qualities of mental images
bioRxiv · 4 Sept 2026 · Preprint
A neuro-computational method reveals mental images are better represented by blurred, low-contrast, and psychedelic-style features, supporting theories of reduced sensory quality.
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https://jclub.com.au/a/10.64898/2026.08.25.747062
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Dronabinol for nightmares in post-traumatic stress disorder: a randomized controlled trial.
Nature Medicine · 1 Sept 2026 · Randomized Controlled Trial
Dronabinol significantly reduces PTSD-related nightmares, showing greater improvement than placebo with a mean CAPS-IV B2 score decrease of -1.50 in a 10-week trial involving 171 adults.
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Adolescent exposure to the psychedelic 25C-NBOMe in rats induces lasting competitive avoidance through disrupted hippocampal-prefrontal synchrony.
Nature Neuroscience · 1 Sept 2026 · Journal Article
Adolescent exposure to 25C-NBOMe causes lasting social avoidance linked to disrupted hippocampal-prefrontal synchrony in rats.
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GPCR endocytosis rewires neuronal gene expression and cellular architecture
bioRxiv · 26 Aug 2026 · Preprint
Beta-adrenergic receptor (β2AR) endosomal signaling induces dendritic growth and synapse formation in neurons, orchestrating gene regulation and cellular architecture.
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https://jclub.com.au/a/10.1101/2025.08.26.672159
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