Diet and metabolism studies

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Moved, week to 23 Oct 2026: 0
Papers in 60 days: 15

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The Dangers of Perverted Appetite.
JAMA · 20 Oct 2026 · Journal Article
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https://jclub.com.au/a/42752729
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Effect of diet macronutrient content on the cardiometabolic response to weight loss: A randomized clinical trial.
Cell Metabolism · 6 Oct 2026 · Randomized Controlled Trial
A very-low-carbohydrate diet yields 2-3 times greater improvements in hepatic insulin sensitivity than Mediterranean or very-low-fat diets during 10% weight loss in metabolically unhealthy obesity.
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https://jclub.com.au/a/42660124
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A Novel NAD+ Supporting Supplement Increased NAD+ Levels, Improved Well-Being, and Alleviated Aging Symptoms: A Double-Blind, Placebo-Controlled Study
medRxiv · 2 Oct 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.05.14.25327611
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Nuclear OXCT1 attenuates histone β-hydroxybutyrylation-mediated MHC-I transcription.
Nature Chemical Biology · 1 Oct 2026 · Journal Article
Nuclear OXCT1 reduces MHC-I gene transcription by suppressing histone β-hydroxybutyrylation in hepatocellular carcinoma cells.
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https://jclub.com.au/a/42204309
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Ketogenic diet is protective during endotoxin-induced lung injury through the elevation of BHB
bioRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.20.753061
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Metabolic benefits of dietary medium-chain fatty acids bypass hepatic ketogenesis
bioRxiv · 17 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.10.08.681190
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Machine learning identifies microbiome and clinical predictors of sustained weight loss following prolonged fasting.
Genome Medicine · 16 Sept 2026 · Randomized Controlled Trial
A 5-day fasting intervention in healthy adults leads to significant short-term weight loss, with partial persistence at 12 weeks, and causes notable shifts in gut microbiome and metabolite profiles.
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https://jclub.com.au/a/42754908
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Shaping sensory-association axis: genetics, transcriptomics, and relation to neuropsychiatry
medRxiv · 10 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.03.03.25323242
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Craving What Matters: Gut-Brain Pathways Drive Essential Amino Acid Appetite.
Gastroenterology · 4 Sept 2026 · Journal Article
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https://jclub.com.au/a/42697336
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Competitive catabolism drives hyperglycemia and hyperinsulinemia in obesity.
Cell Metabolism · 1 Sept 2026 · Journal Article
Competitive catabolism of fatty acids and glucose in obesity causes hyperglycemia and hyperinsulinemia, driven by a physiological circuit identified through modeling.
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https://jclub.com.au/a/42480542
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Exercise-induced liver-to-brain communication in aging and Alzheimer's disease.
Journal of hepatology · 1 Sept 2026 · Journal Article
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https://jclub.com.au/a/42420075
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Combination therapy in metabolic dysfunction-associated steatohepatitis.
The lancet. Gastroenterology & hepatology · 1 Sept 2026 · Journal Article
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WITHDRAWN: Gabapentin in the Management of Meal-time Anxiety in Restrictive Eating Disorders
medRxiv · 31 Aug 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.08.06.25332917
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ALG-055009 in non-cirrhotic adults with metabolic dysfunction-associated steatohepatitis (HERALD): a randomised, double-blind, placebo-controlled, phase 2a trial.
The lancet. Gastroenterology & hepatology · 26 Aug 2026 · Randomized Controlled Trial
ALG-055009 significantly reduces liver fat in non-cirrhotic adults with MASH, with up to 33.2% relative decrease at higher doses in a phase 2a trial.
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Time to Eat: Effects of Personalized Regular Meal Schedules on Body Weight and Mental and Physical Well-Being - A Randomized Controlled Pilot Trial
medRxiv · 25 Aug 2026 · Preprint
Personalized regular meal schedules lead to an average weight loss of 2.10 kg and improved sleep quality in adults with BMI ≥22 kg/m2 over six weeks.
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https://jclub.com.au/a/10.1101/2024.01.30.24301983
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