Stabilizing G-quadruplexes with pyridostatin reduces NF-κB-dependent inflammatory gene expression in lipopolysaccharide-stimulated mouse macrophages.
- Open access
NF-κB Signaling Pathways
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Epithelial NF-κB activity promotes a protective Treg cell response that is crucial for resolving intestinal inflammation in colitis.
- Open access
Geranylgeranyltransferase type II (GGTase II) is essential for B-cell activation, proliferation, and plasma cell survival, with its inhibition reducing autoimmune disease activity in mice.
ABTB1 functions as an E3 ubiquitin ligase that promotes STAT3 degradation, suppressing Th17 cell differentiation and reducing autoimmune inflammation.
Caspase-3 cleaves CYLD at a novel site to limit interferon signaling during mitochondrial apoptosis, reducing inflammation and promoting immune silence.
- Open access
Inhibiting TAK1 in pancreatic ductal adenocarcinoma enhances immune infiltration and activates DNA damage pathways, with significant effects observed in mouse models.
- Open access
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Topics moving, week to 23 Oct 2026
- Single-cell and spatial transcriptomics6
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- Alzheimer's disease research and treatments3
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