A human-specific antibody selectively inhibits interleukin-6 trans-signalling while preserving classic signalling, revealing distinct receptor assembly mechanisms.
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Cytokine Signaling Pathways and Interactions
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High JAK-STAT pathway activity in breast cancer correlates with improved immunotherapy response, especially in triple-negative breast cancer patients, serving as a predictive biomarker.
- Open access
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A 12-amino-acid stretch within the STAT5 transactivation domain is essential for its nuclear import, with residues D754 and D758 being critical for this process.
- Open access
Selective targeting of IL-6 trans-signalling may improve safety and efficacy in treating inflammatory diseases by differentiating from classic signalling pathways.
Strong, sustained type I IFN signaling intrinsically impairs IFNγ responses in macrophages, increasing susceptibility to tuberculosis in Mycobacterium tuberculosis infection.
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