Click Chemistry and Applications
Moving in Nature Chemical Biology, bioRxiv, Nature, Nature Communications and Nature Biotechnology.
- Moved, week to 23 Oct 2026
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- Papers in 60 days
- 37
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Latest in Click Chemistry and Applications
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Tryptoline acrylamide stereoprobes can disrupt the GRPEL1-HSPA9 complex by targeting nonorthosteric sites, impairing mitochondrial protein import and mitophagy.
- Open access
- 1 cites
Artificial metalloenzymes can be engineered to function in complex biological environments such as cell lysates, on cell surfaces, and intracellularly, despite challenges.
CLEO4-88 acts as a molecular glue with an EC50 of 12.5 nM to inhibit ACAA1 thiolase activity by inducing binding to GID4 in vitro and in cellulo.
- 1 cites
Monovalent degraders can recruit two E3 ligases, DCAF16 and FBXO22, to degrade SMARCA2/4, with ligase dependency being chemically and genetically tunable.
- Open access
- 2 cites
PRADA enables in vivo proximity labeling of proteins and RNAs across multiple organisms, revealing RNA folding as a key regulator of mitochondrial gene expression.
Bispecific antibody chimeras (GTACs) induce receptor degradation, achieving over 100-fold greater potency than traditional antagonists for multiple GPCRs.
- Open access
Bitopic kinase inhibitors designed with optimized parameters can surpass existing drugs like ponatinib in potency and safety, especially against resistant ABL1 mutants.
- Open access
Heterobifunctional protein binders achieve cell-type-specific targeting with subnanomolar potency via FKBP12-dependent enrichment.
- Open access
Lantern achieves sub-minute, spatially precise RNA and protein labeling in eukaryotic cells, enabling detailed mapping of subcellular molecular networks.
- Open access
- 1 cites
High-throughput chemical modification of ligands yields 3,163 compounds, leading to the discovery of novel chemical inducers of proximity with therapeutic potential.
- Open access
- 5 cites
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Journals this month
- bioRxiv6157
- medRxiv1716
- PNAS447
- Sci Adv354
- JAMA262
- Environ Res230
- BMJ200
- Environ Pollution165
- Nat Commun161
- Science141
- Nature138
- Cell Rep130
- Lancet128
- NEJM119
- Curr Biol108
- mBio107
- Plant Cell Environ107
- J Exp Bot106
Topics moving, week to 23 Oct 2026
- Single-cell and spatial transcriptomics6
- Neuroinflammation and Neurodegeneration Mechanisms5
- Bacteriophages and microbial interactions5
- Gut microbiota and health5
- Genomics and Phylogenetic Studies4
- Cancer Genomics and Diagnostics4
- Cancer Immunotherapy and Biomarkers4
- Alzheimer's disease research and treatments3
- Inflammatory Bowel Disease3
- Influenza Virus Research Studies3