Innovative Microfluidic and Catalytic Techniques Innovation

Moving in bioRxiv, Biotechnology advances, medRxiv, Nature Chemical Biology and Nature Communications.

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CascadeMAP: Autonomous Closed-loop Optimization of Enzyme Cascades via Microfluidics, Machine Learning and Agentic AI
bioRxiv · 21 Oct 2026 · Preprint
CascadeMAP autonomously optimized enzyme cascades using microfluidics, machine learning, and agentic AI, processing approximately 295,000 reactions across 7,400 conditions in 7 days.
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https://jclub.com.au/a/10.64898/2026.06.04.730034
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Liquid-liquid phase separation in metabolic engineering: Mechanistic insights, emerging applications, and future challenges.
Biotechnology advances · 1 Oct 2026 · Review
Liquid-liquid phase separation (LLPS) enables precise regulation of metabolic activities and biochemical networks through membraneless organelles, advancing metabolic engineering.
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https://jclub.com.au/a/42225537
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FoldMark: Safeguarding Protein Structure Generative Models with Distributional and Evolutionary Watermarking
bioRxiv · 26 Sept 2026 · Preprint
FoldMark achieves over 95% watermark accuracy at 32 bits in protein generative models without compromising structural quality.
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https://jclub.com.au/a/10.1101/2024.10.23.619960
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Computational design of a thermostable α-helical barrel protein with tunable active-site positioning
bioRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2024.10.07.617055
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Deep Learning-Driven Pattern Analysis of Dried E. coli-Laden Urine Deposits for Point-of-Care Diagnostics
medRxiv · 5 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.10.14.25337322
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Effect of human urinary microenvironment and fluid flow on antibiotic and phage therapy efficacy against uropathogenic Escherichia coli.
Nature Communications · 4 Sept 2026 · Journal Article
Microenvironmental factors in the human urinary system significantly reduce the effectiveness of antibiotics and phages against uropathogenic Escherichia coli, especially under flow conditions.
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https://jclub.com.au/a/42697898
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Lighting up lipid droplets.
Nature Chemical Biology · 1 Sept 2026 · Journal Article
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https://jclub.com.au/a/41957279
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Suppressing Primer-Driven Nonspecific Amplification in LAMP Using TrueLAMP
bioRxiv · 30 Aug 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.10.23.684253
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