Receptor Mechanisms and Signaling

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Development of a genetically encoded fluorescent indicator for monitoring GPR52 activation
bioRxiv · 14 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.03.11.711017
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Selective inhibition of IL-6 trans-signalling reveals distinct mechanisms of human classic and trans-signalling receptor-complex formation.
Communications Biology · 14 Oct 2026 · Journal Article
A human-specific antibody selectively inhibits interleukin-6 trans-signalling while preserving classic signalling, revealing distinct receptor assembly mechanisms.
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https://jclub.com.au/a/42875473
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Allosteric disulfide control of ligand binding and endocytosis of KIR2DL4, the natural killer cell receptor for HLA-G.
eLife · 13 Oct 2026 · Journal Article
Allosteric disulfide bond switching in KIR2DL4 regulates HLA-G binding and endocytosis, with the Cys10-Cys28 bond controlling receptor activation in human NK cells.
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https://jclub.com.au/a/42867135
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Sequence context decodes multi-state conformational heterogeneity from crystallographic B-factors
bioRxiv · 11 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2025.12.05.692009
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Protein Language Model-Conditioned Graph Neural Networks for Multitask Ligand Activity Prediction Across Human GPCRs
bioRxiv · 10 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.27.754816
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Dynamic RhoA-Mediated Remodeling of Ordered Membrane Domains
bioRxiv · 6 Oct 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.06.18.658998
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Selective suppression and biasing of chemokine receptors CCR9 and ACKR4 through targeting CCL25 with de novo miniproteins
bioRxiv · 5 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.01.23.701245
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GalaxyMemMD: an end-to-end Galaxy toolset for reproducible membrane embedding, molecular dynamics simulation, and analysis of membrane proteins
bioRxiv · 4 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.28.755125
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A cholinergic hub in the nucleus accumbens gates opioid-reward learning.
Nature · 1 Oct 2026 · Journal Article
Blocking cholinergic interneurons in the nucleus accumbens prevents morphine-conditioned place preference without affecting dopamine increases in mice.
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https://jclub.com.au/a/42557321
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GPCR antagonism via rewiring of receptor trafficking and degradation.
Nature · 30 Sept 2026 · Journal Article
Bispecific antibody chimeras (GTACs) induce receptor degradation, achieving over 100-fold greater potency than traditional antagonists for multiple GPCRs.
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https://jclub.com.au/a/42816619
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Precision editing of an aggression-encoding network relay suppresses violent action in mice
bioRxiv · 28 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2022.12.07.519272
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PCO371 intracellular agonism at the parathyroid hormone 1 receptor produces pan-activation of signalling partners
bioRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.05.27.728112
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Structural basis of stepwise G protein activation by the viral chemokine receptor US28
bioRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2025.12.10.692789
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Individual Taste Preferences Predict Cortical Taste Dynamics but Are Modified by Experience
bioRxiv · 22 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2024.04.02.587752
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TCF25 emerges as a cytoplasmic regulator of GPRASP2 stability
bioRxiv · 22 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.04.09.714440
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Speckle-tracking echocardiography in preclinical mouse models: Implications for cancer therapy-related cardiac dysfunction from inhibition of the extracellular signal-regulated kinase 1/2 (ERK1/2) cascade
bioRxiv · 22 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.05.16.654397
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Pharmacological and Transcriptomic Exploration of β2-Adrenergic Receptor-Gα15 Signaling in THP-1-Derived Macrophages
bioRxiv · 22 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.02.09.704723
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Uncoupling of the allosteric signalling network in the β(1)-adrenergic receptor by a negative allosteric modulator.
Nature Communications · 18 Sept 2026 · Journal Article
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https://jclub.com.au/a/42897158
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Shared and unique chromatin accessibility and 3D functional interactions of substance use disorder loci implicate cell types beyond the brain
medRxiv · 18 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2024.07.18.24310649
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Structure based discovery of antipsychotic-like TAAR1 agonists.
Nature Communications · 17 Sept 2026 · Journal Article
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https://jclub.com.au/a/42894001
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A directed TM->JM coupling in receptor tyrosine kinase dimers, set by activating mutations and the membrane environment
bioRxiv · 17 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.05.22.727318
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The left PBN to aCM pathway mediates pain-related aversion in male mice.
Cell Reports · 17 Sept 2026 · Journal Article
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https://jclub.com.au/a/42752087
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Development of a random background to understand ligand optimization.
Nature · 16 Sept 2026 · Journal Article
11.3% of randomly modified ligands across six targets improved potency tenfold or more, revealing a surprising baseline for ligand optimization success.
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https://jclub.com.au/a/42749805
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Dual-mode tethered intramolecular agonist-dependent mechanoactivation of the adhesion GPCR ADGRG1/GPR56
bioRxiv · 15 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.09.16.676693
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QuantiTrack: A unified software to study protein dynamics in living cells
bioRxiv · 15 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.02.19.706877
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Heterotrimeric G proteins containing Gβ1γ2 subunits exhibit subtype-specific mobility differences in live cells
bioRxiv · 14 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.04.13.718213
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Discovery of an antagonist nanobody targeting the oxytocin receptor with tocolytic effect in mice.
Nature Communications · 11 Sept 2026 · Journal Article
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https://jclub.com.au/a/42864336
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Modulation of human dorsal root ganglion neuron excitability by Nav1.7 inhibition
bioRxiv · 11 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.03.26.714428
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Intersection of transient cell states with stable cell types in hippocampus
bioRxiv · 9 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.10.17.683151
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ProteinSage: From implicit learning to explicit structural constraints for efficient protein language modeling
bioRxiv · 9 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.03.17.712034
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