Diabetes and associated disorders

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Role of GLP1-receptor signaling and α-β-cell communication in functional β-cell heterogeneity.
bioRxiv · 16 Oct 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.04.25.650736
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Genome-wide association and Mendelian randomization analyses of host response to Helicobacter pylori infection implicate HLA polymorphisms and immune-mediated diseases.
medRxiv · 14 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.03.27.26349357
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A surviving beta cell subpopulation enriched in patients with T1D
bioRxiv · 10 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.05.15.725449
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The G protein-coupled receptor GPR31 governs inflammatory signaling in the pancreatic islet microenvironment
bioRxiv · 8 Oct 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.10.02.680021
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Glutamine metabolism as a rheostat of CD4(+) T cell pathogenic function in metabolic dysfunction-associated steatotic liver disease.
Cell Metabolism · 6 Oct 2026 · Journal Article
Hepatic glutamine depletion is linked with increased CD4+ T cell inflammation and worsened liver damage in MASLD patients and mouse models.
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https://jclub.com.au/a/42759512
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Transcriptionally distinct atypical B cell populations contribute to insulin autoreactivity and show differential activation, isotype switching, and somatic hypermutation in early-stage type 1 diabetes individuals
bioRxiv · 2 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.30.754202
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Metabolic switch: lymphocytes and the onset of T-cell-mediated autoimmunity.
Cellular & molecular immunology · 1 Oct 2026 · Review
Alterations in glycolysis, mitochondrial function, and mTOR signaling in lymphocytes are linked to the development of T-cell-mediated autoimmunity in diseases like MS, RA, and T1D.
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https://jclub.com.au/a/42634089
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MARCH2/3 target FcγRI for K27-linked polyubiquitination and degradation to restrict the inflammatory response.
Cellular & molecular immunology · 1 Oct 2026 · Journal Article
MARCH2 and MARCH3 redundantly target FcγRI for K27-linked polyubiquitination and lysosomal degradation, limiting inflammatory responses in mice.
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https://jclub.com.au/a/42595851
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The ISChip: A high-throughput qPCR array for absolute quantification of insertion sequences across the One Health continuum.
Environmental pollution · 1 Oct 2026 · Journal Article
ISChip enables absolute quantification of 183 prevalent insertion sequences across diverse environmental samples with a sensitivity of 23-28 copies per reaction.
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https://jclub.com.au/a/42349820
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γδ T cell receptor dependencies define a unique immunosurveillance modality.
Nature · 30 Sept 2026 · Journal Article
γδ T cell receptor (TCRγδ) dependencies define a distinct immunosurveillance modality crucial for rapid tissue stress and carcinogenesis responses.
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https://jclub.com.au/a/42816614
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Long-term environmental exposures and Diabetes Mellitus type 2 incidence in over 240,000 Dutch adults.
Environmental research · 15 Sept 2026 · Journal Article
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https://jclub.com.au/a/42492750
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The C3-C3aR axis modulates trained immunity in alveolar macrophages.
eLife · 10 Sept 2026 · Journal Article
C3-C3aR signaling enhances trained immunity in alveolar macrophages, with C3 deficiency impairing cytokine production and metabolic activity in mice.
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https://jclub.com.au/a/42720115
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Retraction notice to "Association between donor and recipient TCF7L2 gene polymorphisms and the risk of new-onset diabetes mellitus after liver transplantation in a Han Chinese population" [J Hepatol 58 (2013) 271-277].
Journal of hepatology · 1 Sept 2026 · Retraction Notice
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Single-cell profiling of the lung immune cells of diabetes-tuberculosis comorbidity reveals reduced type-II interferon and elevated Th17 responses.
bioRxiv · 27 Aug 2026 · Preprint
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https://jclub.com.au/a/10.1101/2024.10.24.619799
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Donor-derived CD8+CD122+ Tregs generated in mixed donor chimeric NOD mice suppress autoreactive T cells
bioRxiv · 26 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.03.20.712252
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