Peroxisome Proliferator-Activated Receptors

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Moved, week to 23 Oct 2026: 0
Papers in 60 days: 12

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Publisher Correction: Microbiota-derived 10-hydroxystearic acid activates PPARα to restore gut epithelial barrier integrity and enhance anti-retroviral therapy.
Nature Microbiology · 16 Oct 2026 · Published Erratum
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Compartment-specific PPARδ activity controls the outcome of cancer-immune cell competition and immunotherapy efficacy.
Nature Immunology · 14 Oct 2026 · Journal Article
Activating PPARδ in immune cells enhances tumor suppression and improves immunotherapy responses in mice with metastatic colorectal cancer.
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WITHDRAWN: USP20 Stabilizes FABP5 to Drive Macrophage Foam Cell Formation and Atherosclerosis
bioRxiv · 5 Oct 2026 · Preprint
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Recruiting without destroying.
Nature Chemical Biology · 1 Oct 2026 · Journal Article
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MTAP loss upregulates BCAT1 in pancreatic cancer and drives branched-chain amino acid dependency.
Cell Reports · 29 Sept 2026 · Journal Article
Loss of MTAP in pancreatic ductal adenocarcinoma (PDAC) increases BCAT1 expression by DNA demethylation, leading to a 2.5-fold BCAA dependency that promotes tumor progression.
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Androgen-PDH axis modulates sexual dimorphism of mitochondrial respiration in visceral fat.
Cell Reports · 22 Sept 2026 · Journal Article
Androgen-AR signaling suppresses mitochondrial respiration in visceral fat by downregulating Pdhb, contributing to sex differences in fat accumulation and metabolic risk.
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ACAD10 encodes two orphan enzymes in the ether lipid biosynthetic and salvage pathways
bioRxiv · 15 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.09.10.675409
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Innovative CRISPR Etf-QO Mutant Knock-in Model Mimics MADD-associated Lipid Storage Myopathy and Reveal Therapeutic Potential of Exercise Intervention
bioRxiv · 14 Sept 2026 · Preprint
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PISD acts as a switch between lipophagy and fatty acid transfer to mitochondria.
Journal of Cell Biology · 7 Sept 2026 · Journal Article
PISD-LD functions as a molecular switch, promoting fatty acid transfer to mitochondria while inhibiting lipophagy, thereby regulating energy production during starvation.
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Arachidonoyl-taurine is elevated in human MASLD and protects against hepatic steatosis and inflammation in preclinical models.
Journal of hepatology · 1 Sept 2026 · Journal Article
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Acetyl-CoA carboxylase carboxyltransferase β subunit enhances NaHCO(3) tolerance and fat content.
Plant Physiology and Biochemistry · 1 Sept 2026 · Journal Article
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SETD6-mediated methylation of PPARγ establishes a transcriptional feedback circuit promoting lipid accumulation in liver-derived cells.
eLife · 28 Aug 2026 · Journal Article
SETD6 methylates PPARγ at K170, creating a positive feedback loop that promotes lipid accumulation in liver-derived cells.
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