HIV/AIDS drug development and treatment

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A Tissue Virus Microenvironment with Activated Stress Responses Underlies Durable SIV Persistence
bioRxiv · 15 Oct 2026 · Preprint
Persistent SIV reservoirs in rhesus macaques are associated with a tissue microenvironment characterized by activated stress responses, metabolic rewiring, and immunosuppressive structures.
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https://jclub.com.au/a/10.64898/2026.04.02.716177
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Distinct allosteric remodeling of HIV-1 Env dynamics on virions by gp41-directed antibodies reveals two modes of neutralization.
eLife · 2 Oct 2026 · Journal Article
Most gp41-directed broadly neutralizing antibodies allosterically stabilize the prefusion-closed Env state, while the bivalent 10E8.4/iMab antibody favors both closed and open states.
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https://jclub.com.au/a/42826053
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Mechanisms of HIV-1 assembly, release and maturation.
Nature Reviews Microbiology · 1 Oct 2026 · Review
Advances in structural biology and imaging have revealed detailed mechanisms of HIV-1 assembly, release, and maturation, informing targeted antiviral strategies.
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https://jclub.com.au/a/42277315
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Finishing the fight against HIV.
Nature Microbiology · 29 Sept 2026 · Editorial
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https://jclub.com.au/a/42811104
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Stability of HIV RNA in plasma stored at different temperatures
medRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.22.26363748
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Efficacy of postmenopausal estrogen replacement in SIV-infected female macaques on antiretroviral therapy.
bioRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.21.746440
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Performance of Rilpivirine-Based Hydrophobic Tags and PROTACs Directed Against HIV-1 Reverse Transcriptase
bioRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.24.753933
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Deconvolution of HIV-1 Mutational Signatures Reveals Dominant and Donor-Specific APOBEC3-Associated Mutagenesis Across Anatomical Compartments
bioRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.23.753842
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Structural basis of lenacapavir-induced HIV-1 capsid defects during virion maturation.
Nature Communications · 22 Sept 2026 · Journal Article
Lenacapavir disrupts HIV-1 capsid maturation by altering interhexamer interactions, preventing functional cone-shaped capsid formation during virion assembly.
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https://jclub.com.au/a/42773142
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Molecular Determinants Governing the Antitubercular Activity of Griselimycin
bioRxiv · 15 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.03.19.712639
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Silent but persistent: Failure of continuous tenofovir based ART to prevent HBV and HDV reactivation under chemotherapy in an HBsAg-negative patient living with HIV.
Journal of hepatology · 2 Sept 2026 · Letter
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https://jclub.com.au/a/42685983
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Covalent anti-HIV compound that induces HIV-1 capsid multimerization and degradation, decomposes the viral core
bioRxiv · 2 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.04.19.649630
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Development of a PCR-based technique for genotyping UGT1A1 gene and distribution of rs3064744 alleles in the Russian population.
Frontiers in Genetics · 26 Aug 2026 · Journal Article
A novel PCR-based method using a 1D-CNN ensemble achieves 100% accuracy in genotyping UGT1A1 rs3064744 alleles, overcoming platform variability in the Russian population.
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https://jclub.com.au/a/42713600
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