Lipoproteins and Cardiovascular Health

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Phenotypic and genetic sex differences in LDL-C and statin treatment in All of Us
medRxiv · 19 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.01.26.26344867
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Electronic health record (EHR)-detectable statin intolerance phenotypes: Prevalence and validation in real-world general practice
medRxiv · 16 Oct 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.11.04.25339533
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Predictors of statin intolerance among statin users in primary care using real-world data
medRxiv · 13 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.02.23.26346866
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Predictors of statin adherence among statin users in primary care using real-world data
medRxiv · 13 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.02.24.26347032
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Interventions to manage intolerance among patients prescribed statins for primary prevention of cardiovascular diseases: A systematic review and meta-analysis
medRxiv · 12 Oct 2026 · Preprint
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LIPC-E97G Gain-of-function variant potentiates the hypocholesterolemic and anti-atherogenic effects of evinacumab in Ldlr-/- mice
bioRxiv · 2 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.28.754893
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A signal to boost cholesterol.
Nature Cell Biology · 1 Oct 2026 · Journal Article
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A Synopsis of the 2025 U.S. Department of Veterans Affairs and U.S. Department of Defense Clinical Practice Guideline for Lipid Management for Cardiovascular Disease Risk Reduction.
Annals of Internal Medicine · 1 Oct 2026 · Practice Guideline
The 2025 VA/DoD lipid management guideline recommends more intensive therapy for high-risk patients, including combination treatments and new risk assessment tools.
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https://jclub.com.au/a/42735406
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Atorvastatin, Cardiovascular Events, and Disability-free Survival in Older Adults.
New England Journal of Medicine · 1 Oct 2026 · Randomized Controlled Trial
Atorvastatin reduces major cardiovascular events by 30% in adults aged 70 and older but does not extend disability-free survival over nearly six years.
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https://jclub.com.au/a/42670961
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Structural basis for rosuvastatin-induced activation of skeletal muscle ryanodine receptor 1.
Nature Communications · 3 Sept 2026 · Journal Article
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The Emerging Role of Treatment Policy Implementation Trials in Acute Coronary Syndrome.
New England Journal of Medicine · 29 Aug 2026 · Editorial
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Prasugrel versus Ticagrelor in Acute Coronary Syndromes.
New England Journal of Medicine · 29 Aug 2026 · Journal Article
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A whole-animal phenotypic drug screen identifies suppressors of atherogenic lipoproteins.
eLife · 27 Aug 2026 · Journal Article
A zebrafish phenotypic drug screen identified seven compounds, including enoxolone, that lower ApoB-containing lipoproteins, highlighting HNF4α as a key regulator.
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Familial Hypercholesterolemia.
JAMA · 25 Aug 2026 · Journal Article
Familial hypercholesterolemia affects both homozygous and heterozygous individuals, requiring tailored assessment, diagnosis, and management strategies.
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