Hematopoietic Stem Cell Transplantation

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Author Correction: A kinetics-based model of haematopoiesis reveals extrinsic regulation of skewed lineage output from stem cells.
Nature Cell Biology · 16 Oct 2026 · Published Erratum
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A ncBAF to cBAF Switch Regulates Human Hematopoietic Progenitor Myeloid Differentiation
bioRxiv · 10 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.10.01.755757
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BRM preserves sinusoidal niche resilience through Jag2-Notch signaling during hematopoietic regeneration and aging
bioRxiv · 8 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.07.03.736310
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External Evaluation and Calibration Drift of Explainable Machine Learning Models for Acute and Chronic GVHD Prediction After Allogeneic HSCT
medRxiv · 8 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.06.14.26355639
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Leptin Receptor+ cells create a perisinusoidal niche for thrombopoiesis in the bone marrow by synthesizing CXCL14
bioRxiv · 5 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.01.27.702029
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Generation of a human induced pluripotent stem cell panel from a family with a heterozygous RPS19 mutation including healthy wild-type, silent carrier and Diamond-Blackfan anemia individuals.
Stem cell research · 1 Oct 2026 · Journal Article
A family with heterozygous RPS19 mutation yielded four iPSC lines representing healthy, silent carrier, and DBA individuals, enabling disease modeling.
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Mesenchymal cells rebuild the thymus.
Nature Biotechnology · 1 Oct 2026 · Journal Article
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FGF18 mediates fibroblast-leukemia cross talk to promote acute myeloid leukemia progression.
Blood · 1 Oct 2026 · Journal Article
Fibroblast-derived FGF18 promotes AML progression and immune suppression by activating FGFR3 signaling and forming a feed-forward loop in the bone marrow niche.
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Mesenchymal thymic niche cells enable regeneration of the adult thymus and T cell immunity.
Nature Biotechnology · 1 Oct 2026 · Journal Article
A Postn+ mesenchymal cell subset is essential for T lymphopoiesis and thymus regeneration, and its transfer enhances T cell production and immune response.
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Spatiotemporal single-cell profiling reveals T cell clonal dynamics and phenotypic plasticity in human graft-versus-host disease.
Nature Immunology · 1 Oct 2026 · Journal Article
Severe graft-versus-host disease is linked to persistent expansion of alloreactive T cell clones that acquire tissue-resident memory programs during migration to epithelium.
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Generation of TWO iPSC lines (CRICKi025-A and CRICKi026-A) from healthy donor bone marrow mesenchymal stromal cells.
Stem cell research · 1 Oct 2026 · Journal Article
Two human iPSC lines reprogrammed from adult bone marrow MSCs are genomically stable and can differentiate into the three germ layers.
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Prefibrotic bone marrow microenvironment is a hallmark of clonal hematopoiesis.
Nature Immunology · 30 Sept 2026 · Journal Article
Fibro-inflammatory remodeling is a hallmark of clonal hematopoiesis of indeterminate potential, with fibroblasts expanding and acquiring cancer-associated transcriptional states.
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Clonal blood reshapes its home.
Nature Immunology · 30 Sept 2026 · Journal Article
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Sorafenib enhances graft-versus-leukemia activity through IL-18-mediated macrophage and NK cell crosstalk in FLT3-ITD acute myeloid leukemia.
Cell Reports · 22 Sept 2026 · Journal Article
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IDH3 regulates citrate homeostasis to control metabolic fitness and venetoclax resistance of AML stem cells.
Blood · 17 Sept 2026 · Journal Article
IDH3A-driven citrate accumulation controls metabolic fitness and venetoclax resistance in AML stem cells, with knockdown impairing leukemia maintenance.
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Translational regulation of Sf1 integrates alternative splicing and hematopoietic stem cell fate.
Blood · 10 Sept 2026 · Journal Article
Translational regulation of Sf1 via a conserved 5' UTR modulates hematopoietic stem cell fate by controlling spliceosome activity and gene splicing.
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CD4+CD25+FOXP3+ regulatory T cells to protect against graft-versus-host disease.
Blood · 10 Sept 2026 · Review
CD4+CD25+FOXP3+ regulatory T cells significantly reduce graft-versus-host disease risk in allogeneic hematopoietic cell transplantation.
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Effect of stem cell infusion time-of-day on acute graft-versus-host disease: a randomized clinical trial
medRxiv · 10 Sept 2026 · Preprint
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Suppressing glutamate dehydrogenase guides hematopoietic stem cell divisions into self-renewal.
Nature Communications · 5 Sept 2026 · Journal Article
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Altered chromatin accessibility mediated by somatic cohesin mutations amplifies FLI1-Menin output to promote leukemogenesis
bioRxiv · 4 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.04.01.646632
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IFN-γ drives long-term bone marrow niche dysfunction following doxorubicin-based chemotherapy.
Blood · 3 Sept 2026 · Journal Article
IFN-γ-driven inflammation causes long-term bone marrow niche dysfunction after doxorubicin chemotherapy, impairing hematopoietic and skeletal health.
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A Robust Computational Workflow Utilizing Generalized Least Squares (GLS) and Generalized Estimating Equations (GEE-GLM) for Longitudinal Flow Cytometry Maturation Data Analysis.
Cytometry. Part A : the journal of the International Society for Analytical Cytology · 1 Sept 2026 · Journal Article
GLS and GEE-GLM modeling approaches reveal significant differences in hematopoietic maturation profiles across disease states, with GEE-GLM highlighting early-stage variations.
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Generation and characterization of human iPSC line SANi013-A from a Diamond-Blackfan anemia syndrome (DBAS) patient carrying a heterozygous RPS26 c.95-98 duplication variant.
Stem cell research · 1 Sept 2026 · Case Reports
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Non-genotoxic transplantation and in vivo selection through epitope editing.
Nature · 1 Sept 2026 · Journal Article
Epitope editing of KIT combined with BCL11A disruption enables non-genotoxic, in vivo selection of gene-edited HSPCs, enhancing therapeutic potential for blood disorders.
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P-selectin delineates conserved functional heterogeneity in early hematopoietic stem cell aging in humans and mice.
EMBO Journal · 1 Sept 2026 · Journal Article
P-selectin marks early functional heterogeneity in aging hematopoietic stem cells, with high expression linked to increased DNA damage and myeloid bias in humans and mice.
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MHC II-expressing bone marrow megakaryocytes are noncanonical antigen presenting cells and activate CD4+ T cells ex vivo
bioRxiv · 27 Aug 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.11.21.689743
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Bone marrow stem cell connexins: misconceptions and new insights.
Blood · 27 Aug 2026 · Review
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