Pain Mechanisms and Treatments

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Moved, week to 23 Oct 2026: 1
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Receptor and cell-type-specific mechanisms in mesocortical dopamine circuits gate chronic pain and comorbid anxiodepression.
Neuron · 11 June 2026 · Journal Article
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Multi-timescale dynamics organize descending pain modulation
bioRxiv · 22 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2025.12.15.693905
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Phasic and tonic pain serve distinct functions during adaptive behaviour
bioRxiv · 19 Oct 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.02.10.637253
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Midbrain somatostatin-expressing cells control pain-suppression during defensive states
bioRxiv · 15 Oct 2026 · Preprint
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https://jclub.com.au/a/10.1101/2022.01.20.476899
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Neuropathic pain drives time-dependent reorganization of naturalistic movement and corticostriatal circuits
bioRxiv · 8 Oct 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.10.07.680927
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Degraded myelin is associated with cold hypersensitivity in paclitaxel-induced peripheral neuropathy
bioRxiv · 7 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.05.29.728780
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Chemically diverse antagonists inhibit human TRPV1 through ligand-specific interaction networks
bioRxiv · 7 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.04.27.721197
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IgG4 sensitizes human dorsal root ganglia neurons and patient-derived IgG induces FcγR-dependent pain hypersensitivity in mice
medRxiv · 2 Oct 2026 · Preprint
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https://jclub.com.au/a/10.1101/2024.11.12.24317004
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E-Selectin Orchestrates IL-1B-Dependent Neuroinflammation via NLRP3 in Vincristine-Induced Neuropathy
bioRxiv · 29 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.03.10.710929
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Epigenetic, chromatin-associated, and epitranscriptomic regulation in chronic pain: mechanisms and translational prospects.
Frontiers in Genetics · 25 Sept 2026 · Review
Locus-, cell-, and stage-specific epigenetic reprogramming, not uniform changes, most consistently underpins mechanisms of chronic pain across models.
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Forsythoside B attenuates neuropathic pain by suppressing USP7/HIF-1α-mediated microglial glycolytic reprogramming
bioRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.20.752649
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Evaluating home-cage-activity metrics for detecting postprocedural pain in a plantar incision mouse model
bioRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.23.753854
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Concordance between the fast and efficient mixed-effects algorithm (FEMA) and conventional mixed-effects modeling for whole-brain connectivity in longitudinal chronic pain
bioRxiv · 25 Sept 2026 · Preprint
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The left PBN to aCM pathway mediates pain-related aversion in male mice.
Cell Reports · 17 Sept 2026 · Journal Article
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https://jclub.com.au/a/42752087
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Modulation of human dorsal root ganglion neuron excitability by Nav1.7 inhibition
bioRxiv · 11 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.03.26.714428
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Precision Functional Mapping of Imagined and Experienced Pain
bioRxiv · 2 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.08.06.668906
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Increased activity in the somatosensory and insular cortex during the transition from acute to chronic neuropathic pain
bioRxiv · 1 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.08.25.747057
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Cocaine-Enhanced Enkephalin Gates Plasticity of Distinct Striatal Synapses and Facilitates Cue-Induced Cocaine-Seeking During Abstinence
bioRxiv · 1 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.03.11.711212
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Interaction of attention and localization of pain maxima shift the balance between lateral inhibition and spatial facilitation in nociceptive processing
bioRxiv · 28 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.03.14.711815
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Myotonic Muscle Activity Drives a Persistent Pain State Responsive to NaV1.8-directed Analgesics
bioRxiv · 25 Aug 2026 · Preprint
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https://jclub.com.au/a/10.1101/2024.06.19.599732
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