Structural basis for protocadherin-1 recognition by New World hantaviruses.

The structure of PCDH1 bound to Andes virus spike reveals how the virus recognizes host cells, with PCDH1 engaging a deep pocket in the spike's Gn protomers.

• Why it matters: Understanding the molecular basis of hantavirus entry is crucial because no approved therapeutics exist for these deadly pathogens, and this knowledge can inform antiviral development.
• What they did: The study used near-atomic resolution structural analysis of PCDH1 bound to the virus spike, identifying key Gn loops involved in receptor binding and how antibodies block this interaction.
• The result: Findings elucidate the structural determinants of hantavirus recognition and suggest strategies for designing therapeutics that target the spike or prevent receptor engagement.