AptViralDB: A repository of experimentally validated antiviral aptamers.

AptViralDB provides a comprehensive, manually curated database of 1,768 experimentally validated antiviral aptamers targeting 40 viral species and 104 molecular targets.

• Why it matters: With rising drug resistance, alternative molecules like aptamers are essential for effective viral disease management, yet a centralized resource for validated aptamers was lacking.
• What they did: The database compiles detailed annotations from literature and existing sources, including predicted secondary structures, MFE values, and a knowledge graph linking aptamers, viruses, and targets, along with search and analysis tools.
• The result: AptViralDB enables researchers to explore antiviral aptamers efficiently, supporting computational and experimental studies, and facilitating the development of novel antiviral strategies.