A cortical-hippocampal communication undergoes rebalancing after new learning.

Reorganization of ACC-CA1 communication after learning involves weakening of ACC-to-CA1 signaling during sleep, especially affecting superficial CA1 neurons.

• Why it matters: Understanding how brain regions coordinate during memory consolidation is crucial for revealing mechanisms underlying learning and memory specificity, which remain poorly understood.
• What they did: The study used a generalized linear model decoder to analyze interactions between the anterior cingulate cortex and CA1 neurons during ripples, identifying changes in communication patterns after learning.
• The result: Findings suggest that ACC activity reallocates the contribution of CA1 neurons during memory formation, with selective suppression of superficial CA1 neurons and stable communication with deep CA1 neurons, highlighting a role for ACC in balancing hippocampal activity during consolidation.