TRIM62 facilitates influenza A virus entry by regulating WASH-dependent endosomal trafficking.

TRIM62 promotes influenza A virus entry by preventing WASH from associating with retromer, enhancing endosomal trafficking necessary for viral internalization.

• Why it matters: Understanding how endocytosis is regulated during viral entry can reveal targets for antiviral strategies. The mechanisms controlling viral uptake and restriction are not fully known, especially regarding host protein interactions.
• What they did: The study used influenza A virus as a model and identified WASH complex subunits, including WASH1 and VPS35, as regulators of viral endocytosis, with TRIM62 modulating their interaction.
• The result: TRIM62 maintains WASH in an endocytically active state, counteracting FAM21-VPS35-mediated restriction, thereby facilitating viral entry and suggesting broader roles in lipid raft-mediated endocytosis.