Drug-microbiome-host interactions: antimicrobial effects of non-antibiotic compounds.

Many non-antibiotic compounds exhibit antibacterial activity, often affecting beneficial bacteria more strongly than pathogenic Enterobacteriaceae in humans.

• Why it matters: Understanding the antimicrobial effects of non-antibiotic compounds is crucial because they can disrupt the human microbiome and promote resistance, impacting infectious and chronic diseases.
• What they did: The review discusses recent advances in molecular mechanisms of non-antibiotic antimicrobial activity and examines factors influencing their effects, based on current scientific research.
• The result: This knowledge may inform clinical practices and guide the development of strategies to mitigate microbiome disruption and antimicrobial resistance associated with non-antibiotic compounds.