KDM6A loss enhances oxidative phosphorylation uncovering tissue-level convergent evolution.

Loss of KDM6A universally activates oxidative phosphorylation across multiple cancer types and tissues, revealing tissue-specific mechanisms and convergent evolution.

• Why it matters: Understanding how KDM6A loss influences mitochondrial activity is crucial because it occurs frequently in various cancers and impacts cellular metabolism, yet the underlying mechanisms remain unclear.
• What they did: The study examined KDM6A's role in solid tumors and multiple myeloma, showing its loss promotes oxidative phosphorylation through distinct pathways: CCDC3/CREB1 in solid tumors and mitochondrial transfer via tunneling nanotubes in myeloma.
• The result: These findings suggest KDM6A acts as a central regulator of mitochondrial function, with tissue-specific partners indicating a convergent evolution of metabolic regulation that could inform targeted therapies.