The Band 3-BLVRB interaction acts as an oxygen-sensitive switch regulating red blood cell metabolism, with hypoxia causing dissociation and metabolic remodeling.
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Hemoglobin structure and function
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Iron deficiency in female mice increases arterial nitric oxide signaling by reducing endothelial holo-α-globin, a process reversible with vascular iron repletion.
The CYB5R3 T117S variant reduces riociguat efficacy by impairing nitric oxide signaling in sickle cell disease patients.
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The Band 3-BLVRB interaction acts as an oxygen-sensitive switch regulating red blood cell metabolism, with hypoxia causing dissociation and metabolic remodeling.
- 3 cites
Genomic and proteomic profiling can transform blood transfusion into a predictive, biologically rich system, enabling personalized and resilient blood products.
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